Role of Immunological Cells in Hepatocellular Carcinoma Disease and Associated Pathways
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Authors
Aasarey, Ram
Yadav, Kajal
Kashyap, Brijendra Kumar
Prabha, Sarit
Kumar, Pramod
Kumar, Anil
Ruokolainen, Janne
Kesari, Kavindra Kumar
Date
2023-12-08
Department
All India Institute of Medical Sciences
Bundelkhand University
Maulana Azad National Institute of Technology
National Institute of Cancer Prevention and Research
Central University of Jharkhand
Department of Applied Physics
Bundelkhand University
Maulana Azad National Institute of Technology
National Institute of Cancer Prevention and Research
Central University of Jharkhand
Department of Applied Physics
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Language
en
Pages
1758-1986
Series
ACS Pharmacology and Translational Science, Volume 6, issue 12
Abstract
Hepatocellular carcinoma (HCC) remains one of the predominant causes of cancer-related mortality across the globe. It is attributed to obesity, excessive alcohol consumption, smoking, and infection by the hepatitis virus. Early diagnosis of HCC is essential, and local treatments such as surgical excision and percutaneous ablation are effective. Palliative systemic therapy, primarily with the tyrosine kinase inhibitor Sorafenib, is used in advanced cases. However, the prognosis for advanced HCC remains poor. This Review additionally describes the pathophysiological mechanisms of HCC, which include aberrant molecular signaling, genomic instability, persistent inflammation, and the paradoxical position of the immune system in promoting and suppressing HCC. The paper concludes by discussing the growing body of research on the relationship between mitochondria and HCC, suggesting that mitochondrial dysfunction may contribute to the progression of HCC. This Review focuses on immunological interactions between different mechanisms of HCC progression, including obesity, viral infection, and alcohol consumption.Description
Publisher Copyright: © 2023 The Authors. Published by American Chemical Society
Keywords
Cirrhosis, HBV, HCV, Hepatocellular carcinoma, NAFLD
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Citation
Aasarey , R , Yadav , K , Kashyap , B K , Prabha , S , Kumar , P , Kumar , A , Ruokolainen , J & Kesari , K K 2023 , ' Role of Immunological Cells in Hepatocellular Carcinoma Disease and Associated Pathways ' , ACS Pharmacology and Translational Science , vol. 6 , no. 12 , pp. 1801-1816 . https://doi.org/10.1021/acsptsci.3c00216