Role of Immunological Cells in Hepatocellular Carcinoma Disease and Associated Pathways

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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Authors

Date

2023-12-08

Department

Department of Applied Physics

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Mcode

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Language

en

Pages

16

Series

ACS Pharmacology and Translational Science, Volume 6, issue 12, pp. 1801-1816

Abstract

Hepatocellular carcinoma (HCC) remains one of the predominant causes of cancer-related mortality across the globe. It is attributed to obesity, excessive alcohol consumption, smoking, and infection by the hepatitis virus. Early diagnosis of HCC is essential, and local treatments such as surgical excision and percutaneous ablation are effective. Palliative systemic therapy, primarily with the tyrosine kinase inhibitor Sorafenib, is used in advanced cases. However, the prognosis for advanced HCC remains poor. This Review additionally describes the pathophysiological mechanisms of HCC, which include aberrant molecular signaling, genomic instability, persistent inflammation, and the paradoxical position of the immune system in promoting and suppressing HCC. The paper concludes by discussing the growing body of research on the relationship between mitochondria and HCC, suggesting that mitochondrial dysfunction may contribute to the progression of HCC. This Review focuses on immunological interactions between different mechanisms of HCC progression, including obesity, viral infection, and alcohol consumption.

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Publisher Copyright: © 2023 The Authors. Published by American Chemical Society

Keywords

Cirrhosis, HBV, HCV, Hepatocellular carcinoma, NAFLD

Other note

DOI

10.1021/acsptsci.3c00216

Citation

Aasarey, R, Yadav, K, Kashyap, B K, Prabha, S, Kumar, P, Kumar, A, Ruokolainen, J & Kesari, K K 2023, 'Role of Immunological Cells in Hepatocellular Carcinoma Disease and Associated Pathways', ACS Pharmacology and Translational Science, vol. 6, no. 12, pp. 1801-1816. https://doi.org/10.1021/acsptsci.3c00216

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https://urn.fi/URN:NBN:fi:aalto-202312117158

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[article-cris] Perustieteiden korkeakoulu / SCI