Microfibers synthesized by wet-spinning of chitin nanomaterials : Mechanical, structural and cell proliferation properties

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorWang, Lingen_US
dc.contributor.authorEzazi, Nazanin Zanjanizadehen_US
dc.contributor.authorLiu, Liangen_US
dc.contributor.authorAjdary, Rubinaen_US
dc.contributor.authorXiang, Wenchaoen_US
dc.contributor.authorBorghei, Maryamen_US
dc.contributor.authorSantos, Helder A.en_US
dc.contributor.authorRojas, Orlando J.en_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorBio-based Colloids and Materialsen
dc.contributor.organizationNanjing Forestry Universityen_US
dc.contributor.organizationUniversity of Helsinkien_US
dc.date.accessioned2020-09-04T07:47:09Z
dc.date.available2020-09-04T07:47:09Z
dc.date.issued2020-08-11en_US
dc.description| openaire: EC/H2020/788489/EU//BioELCell
dc.description.abstractPartially deacetylated chitin nanofibers (ChNF) were isolated from shell residues derived from crab biomass and used to prepare hydrogels, which were easily transformed into continuous microfibers by wet-spinning. We investigated the effect of ChNF solid content, extrusion rate and coagulant type, which included organic (acetone) and alkaline (NaOH and ammonia) solutions, on wet spinning. The properties of the microfibers and associated phenomena were assessed by tensile strength, quartz crystal microgravimetry, dynamic vapor sorption (DVS), thermogravimetric analysis and wide-angle X-ray scattering (WAXS). The as-spun microfibers (14 GPa stiffness) comprised hierarchical structures with fibrils aligned in the lateral direction. The microfibers exhibited a remarkable water sorption capacity (up to 22 g g(-1)), while being stable in the wet state (50% of dry strength), which warrants consideration as biobased absorbent systems. In addition, according to cell proliferation and viability of rat cardiac myoblast H9c2 and mouse bone osteoblast K7M2, the wet-spun ChNF microfibers showed excellent results and can be considered as fully safe for biomedical uses, such as in sutures, wound healing patches and cell culturing.en
dc.description.versionPeer revieweden
dc.format.extent10
dc.format.extent29450-29459
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWang, L, Ezazi, N Z, Liu, L, Ajdary, R, Xiang, W, Borghei, M, Santos, H A & Rojas, O J 2020, ' Microfibers synthesized by wet-spinning of chitin nanomaterials : Mechanical, structural and cell proliferation properties ', RSC Advances, vol. 10, no. 49, pp. 29450-29459 . https://doi.org/10.1039/d0ra06178fen
dc.identifier.doi10.1039/d0ra06178fen_US
dc.identifier.issn2046-2069
dc.identifier.otherPURE UUID: e7c9f0dd-04ff-4bd1-bf96-4e06d0ea626cen_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/e7c9f0dd-04ff-4bd1-bf96-4e06d0ea626cen_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85090410154&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/51070411/d0ra06178f.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/46361
dc.identifier.urnURN:NBN:fi:aalto-202009045304
dc.language.isoenen
dc.publisherROYAL SOC CHEMISTRY
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/788489/EU//BioELCellen_US
dc.relation.ispartofseriesRSC Advancesen
dc.relation.ispartofseriesVolume 10, issue 49en
dc.rightsopenAccessen
dc.subject.keywordCELLULOSE NANOFIBERSen_US
dc.subject.keywordCHITOSANen_US
dc.subject.keywordSKINen_US
dc.subject.keywordFILAMENTSen_US
dc.subject.keywordFIBERSen_US
dc.subject.keywordDEACETYLATIONen_US
dc.subject.keywordPERFORMANCEen_US
dc.subject.keywordHYDROGELen_US
dc.titleMicrofibers synthesized by wet-spinning of chitin nanomaterials : Mechanical, structural and cell proliferation propertiesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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