Ionic current inversion in pressure-driven polymer translocation through nanopores

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2015
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Mcode
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Language
en
Pages
1-5
Series
PHYSICAL REVIEW LETTERS, Volume 114, issue 8
Abstract
We predict streaming current inversion with multivalent counterions in hydrodynamically driven polymer translocation events from a correlation-corrected charge transport theory including charge fluctuations around mean-field electrostatics. In the presence of multivalent counterions, electrostatic many-body effects result in the reversal of the DNA charge. The attraction of anions to the charge-inverted DNA molecule reverses the sign of the ionic current through the pore. Our theory allows for a comprehensive understanding of the complex features of the resulting streaming currents. The underlying mechanism is an efficient way to detect DNA charge reversal in pressure-driven translocation experiments with multivalent cations.
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Keywords
charged liquid, polymer translocation
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Citation
Buyukdagli , S , Blossey , R & Ala-Nissila , T 2015 , ' Ionic current inversion in pressure-driven polymer translocation through nanopores ' , Physical Review Letters , vol. 114 , no. 8 , 088303 , pp. 1-5 . https://doi.org/10.1103/PhysRevLett.114.088303