Microscopic Mechanism for Cold Denaturation

Simple item page
dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorDias, C.
dc.contributor.authorAla-Nissila, T.
dc.contributor.authorKarttunen, M.
dc.contributor.authorVattulainen, Ilpo
dc.contributor.authorGrant, M.
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.groupauthorMultiscale Statistical and Quantum Physicsen
dc.date.accessioned2025-10-08T07:12:02Z
dc.date.available2025-10-08T07:12:02Z
dc.date.issued2008
dc.description.abstractWe elucidate the mechanism of cold denaturation through constant-pressure simulations for a model of hydrophobic molecules in an explicit solvent. We find that the temperature dependence of the hydrophobic effect induces, facilitates, and is the driving force for cold denaturation. The physical mechanism underlying this phenomenon is identified as the destabilization of hydrophobic contact in favor of solvent-separated configurations, the same mechanism seen in pressure-induced denaturation. A phenomenological explanation proposed for the mechanism is suggested as being responsible for cold denaturation in real proteins.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdf
dc.identifier.citationDias, C, Ala-Nissila, T, Karttunen, M, Vattulainen, I & Grant, M 2008, 'Microscopic Mechanism for Cold Denaturation', Physical Review Letters, vol. 100, no. 11, 118101, pp. 1-4. https://doi.org/10.1103/PhysRevLett.100.118101en
dc.identifier.doi10.1103/PhysRevLett.100.118101
dc.identifier.issn0031-9007
dc.identifier.issn1079-7114
dc.identifier.otherPURE UUID: 8ec3a4f7-88d7-40a1-9b50-fdaecbe8ea6a
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/8ec3a4f7-88d7-40a1-9b50-fdaecbe8ea6a
dc.identifier.otherPURE LINK: http://link.aps.org/abstract/PRL/v100/e118101
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/13366746/PhysRevLett.100.118101.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/139714
dc.identifier.urnURN:NBN:fi:aalto-202510087895
dc.language.isoenen
dc.publisherAmerican Physical Society
dc.relation.ispartofseriesPhysical Review Lettersen
dc.relation.ispartofseriesVolume 100, issue 11, pp. 1-4en
dc.rightsopenAccessen
dc.subject.keyworddenaturation
dc.subject.keywordprotein
dc.subject.keywordprotein unfolding
dc.titleMicroscopic Mechanism for Cold Denaturationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
PhysRevLett.100.118101.pdf
Size:
494.37 KB
Format:
Adobe Portable Document Format
Download

Collections

[article-cris] Perustieteiden korkeakoulu / SCI