Small effects of electric field on motor cortical excitability following anodal tDCS
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2024-02-16
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Language
en
Pages
16
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iScience, Volume 27, issue 2
Abstract
The dose-response characteristics of transcranial direct current stimulation (tDCS) remain uncertain but may be related to variability in brain electric fields due to individual anatomical factors. Here, we investigated whether the electric fields influence the responses to motor cortical tDCS. In a randomized cross-over design, 21 participants underwent 10 min of anodal tDCS with 0.5, 1.0, 1.5, or 2.0 mA or sham. Compared to sham, all active conditions increased the size of motor evoked potentials (MEP) normalized to the pre-tDCS baseline, irrespective of anterior or posterior magnetic test stimuli. The electric field calculated in the motor cortex of each participant had a nonlinear effect on the normalized MEP size, but its effects were small compared to those of other participant-specific factors. The findings support the efficacy of anodal tDCS in enhancing the MEP size but do not demonstrate any benefits of personalized electric field modeling in explaining tDCS response variability.Description
Funding Information: This work was supported by Academy of Finland (grant number 325326 to I.L.) and JSPS KAKENHI (grant number 20H04050 to S.T. and 21H04956 to A.H.). Publisher Copyright: © 2024 The Author(s)
Keywords
Behavioral neuroscience, Biological sciences, Neuroscience, Techniques in neuroscience
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Citation
Laakso, I, Tani, K, Gomez-Tames, J, Hirata, A & Tanaka, S 2024, ' Small effects of electric field on motor cortical excitability following anodal tDCS ', iScience, vol. 27, no. 2, 108967 . https://doi.org/10.1016/j.isci.2024.108967