Advanced Pipeline for Designing Multi-Locus TMS Coils with Current Density Constraints

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorRissanen, Ilkka J.
dc.contributor.authorSouza, Victor H.
dc.contributor.authorNieminen, Jaakko O.
dc.contributor.authorKoponen, Lari M.
dc.contributor.authorIlmoniemi, Risto J.
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.contributor.departmentUniversity of Birmingham
dc.date.accessioned2023-02-20T05:12:42Z
dc.date.available2023-02-20T05:12:42Z
dc.date.issued2023-07-01
dc.description| openaire: EC/H2020/810377/EU//ConnectToBrain
dc.description.abstractObjective: This work aims for a method to design manufacturable windings for transcranial magnetic stimulation (TMS) coils with fine control over the induced electric field (E-field) distributions. Such TMS coils are required for multi-locus TMS (mTMS). Methods: We introduce a new mTMS coil design workflow with increased flexibility in target E-field definition and faster computations compared to our previous method. We also incorporate custom current density and E-field fidelity constraints to ensure that the target E-fields are accurately reproduced with feasible winding densities in the resulting coil designs. We validated the method by designing, manufacturing, and characterizing a 2-coil mTMS transducer for focal rat brain stimulation. Results: Applying the constraints reduced the computed maximum surface current densities from 15.4 and 6.6 kA/mm to the target value 4.7 kA/mm, yielding winding paths suitable for a 1.5-mm-diameter wire with 7-kA maximum currents while still replicating the target E-fieldswith the predefined 2.8% maximum error in the FOV. The optimization time was reduced by two thirds compared to our previous method. Conclusion: The developed method allowed us to design a manufacturable, focal 2-coil mTMS transducer for rat TMS impossible to attain with our previous design workflow. Significance: The presented workflow enables considerably faster design and manufacturing of previously unattainable mTMS transducers with increased control over the induced E-field distribution and winding density, opening new possibilities for brain research and clinical TMS.en
dc.description.versionPeer revieweden
dc.format.extent9
dc.format.extent1-9
dc.format.mimetypeapplication/pdf
dc.identifier.citationRissanen , I J , Souza , V H , Nieminen , J O , Koponen , L M & Ilmoniemi , R J 2023 , ' Advanced Pipeline for Designing Multi-Locus TMS Coils with Current Density Constraints ' , IEEE Transactions on Biomedical Engineering , vol. 70 , no. 7 , pp. 2025-2034 . https://doi.org/10.1109/TBME.2023.3234119en
dc.identifier.doi10.1109/TBME.2023.3234119
dc.identifier.issn0018-9294
dc.identifier.otherPURE UUID: 54708b8d-74e6-42ae-83f8-cdd6824804fc
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/54708b8d-74e6-42ae-83f8-cdd6824804fc
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85147233443&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/116281801/Advanced_Pipeline_for_Designing_Multi_Locus_TMS_Coils_With_Current_Density_Constraints.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/119766
dc.identifier.urnURN:NBN:fi:aalto-202302202113
dc.language.isoenen
dc.publisherIEEE
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/810377/EU//ConnectToBrain
dc.relation.ispartofseriesIEEE Transactions on Biomedical Engineeringen
dc.rightsopenAccessen
dc.subject.keywordCoil design
dc.subject.keywordcoil optimization
dc.subject.keywordCoils
dc.subject.keywordCurrent density
dc.subject.keywordcurrent density
dc.subject.keywordmTMS
dc.subject.keywordmulti-locus TMS
dc.subject.keywordOptimization
dc.subject.keywordTMS
dc.subject.keywordtranscranial magnetic stimulation
dc.subject.keywordTranscranial magnetic stimulation
dc.subject.keywordTransducers
dc.subject.keywordWindings
dc.subject.keywordWires
dc.titleAdvanced Pipeline for Designing Multi-Locus TMS Coils with Current Density Constraintsen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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