Synthesis and characterization of cellulose-derived polymers for the treatment of damaged cartilage
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Kemian tekniikan korkeakoulu |
Master's thesis
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Authors
Date
2017-06-13
Department
Major/Subject
Biomaterials Science
Mcode
CHEM3041
Degree programme
Nordic Master Program in Polymer Technology
Language
en
Pages
61+4
Series
Abstract
Carboxymethyl cellulose (CMC) is currently the most widely used cellulose derivative and considered as a promising biomaterial due to its biocompatibility, biodegradability and non-toxicity. Polyethylene glycol grafted carboxymethyl cellulose (CMC-g-PEG) has been proved to be a very lubricating polymer. This MSc. thesis work aims to study further the potential application of the lubricating CMC-g-PEG for the treatment of damaged cartilage. CMC-g-PEG with different PEG chain lengths were successfully synthesized and characterized by conductometric titration and Fourier transform infrared spectroscopy. Polyethylene glycol grafted dialdehyde carboxymethyl cellulose (DCMC-g-PEG) was synthesized by oxidation of CMC-g-PEG with sodium periodate. The adsorption of the different polymers on collagen IV films (first approach model for cartilage) was studied by quartz crystal microbalance with dissipation. Compared with dialyzed CMC and CMC-g-PEG, much more DCMC-g-PEG absorbed onto the surface of collagen IV films due to the existence of covalently binding between aldehyde groups of DCMC-g-PEG and amine groups of collagens. The adsorption results of CMC-g-PEG and DCMC-g-PEG provide the evidence that the introduction of aldehyde groups to the backbone of CMC-g-PEG can improve its attaching ability to collagen IV.Description
Supervisor
Österberg, MonikaThesis advisor
Valle-Delgado, Juan JoséKeywords
CMC, CMC-g-PEG, DCMC-g-PEG, osteoarthritis, cartilage, attaching ability