Adipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorAcheva, Annaen_US
dc.contributor.authorKärki, Tyttien_US
dc.contributor.authorSchaible, Niccoleen_US
dc.contributor.authorKrishnan, Ramaswamyen_US
dc.contributor.authorTojkander, Sarien_US
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.groupauthorActive Matteren
dc.contributor.organizationUniversity of Helsinkien_US
dc.contributor.organizationHarvard Medical Schoolen_US
dc.date.accessioned2021-02-09T09:06:59Z
dc.date.available2021-02-09T09:06:59Z
dc.date.issued2021-01-06en_US
dc.description.abstractIn postmenopausal women, a major risk factor for the development of breast cancer is obesity. In particular, the adipose tissue-derived adipokine leptin has been strongly linked to tumor cell proliferation, migration, and metastasis, but the underlying mechanisms remain unclear. Here we show that treatment of normal mammary epithelial cells with leptin induces EMT-like features characterized by higher cellular migration speeds, loss of structural ordering of 3D-mammo spheres, and enhancement of epithelial traction forces. Mechanistically, leptin triggers the phosphorylation of myosin light chain kinase-2 (MLC-2) through the interdependent activity of leptin receptor and Ca2+ channels. These data provide evidence that leptin-activated leptin receptors, in co-operation with mechanosensitive Ca2+ channels, play a role in the development of breast carcinomas through the regulation of actomyosin dynamics.en
dc.description.versionPeer revieweden
dc.format.extent13
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationAcheva, A, Kärki, T, Schaible, N, Krishnan, R & Tojkander, S 2021, ' Adipokine Leptin Co-operates With Mechanosensitive Ca 2 + -Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cells ', Frontiers in Cell and Developmental Biology, vol. 8, 607038 . https://doi.org/10.3389/fcell.2020.607038en
dc.identifier.doi10.3389/fcell.2020.607038en_US
dc.identifier.issn2296-634X
dc.identifier.otherPURE UUID: a5af6fe2-9a87-48f1-9c9a-539afc25da56en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/a5af6fe2-9a87-48f1-9c9a-539afc25da56en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85099726859&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/55788932/Acheva_Adipokine.fcell_08_607038.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/102660
dc.identifier.urnURN:NBN:fi:aalto-202102091960
dc.language.isoenen
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Cell and Developmental Biologyen
dc.relation.ispartofseriesVolume 8en
dc.rightsopenAccessen
dc.subject.keywordactinen_US
dc.subject.keywordactomyosinen_US
dc.subject.keywordadipokinesen_US
dc.subject.keywordcalciumen_US
dc.subject.keywordepitheliumen_US
dc.titleAdipokine Leptin Co-operates With Mechanosensitive Ca2 +-Channels and Triggers Actomyosin-Mediated Motility of Breast Epithelial Cellsen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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