The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorGasik, Michael
dc.contributor.authorZühlke, Alexandra
dc.contributor.authorHaaparanta, Anne-Marie
dc.contributor.authorMuhonen, Virpi
dc.contributor.authorLaine, Kaisa
dc.contributor.authorBilotsky, Yevgen
dc.contributor.authorKellomäki, Minna
dc.contributor.authorKiviranta, Ilkka
dc.contributor.departmentMaterials Processing and Powder Metallurgy
dc.contributor.departmentDepartment of Chemical and Metallurgical Engineering
dc.contributor.departmentTampere University of Technology
dc.contributor.departmentUniversity of Helsinki
dc.contributor.departmentSeqvera
dc.date.accessioned2018-12-10T10:23:07Z
dc.date.available2018-12-10T10:23:07Z
dc.date.issued2018
dc.description| openaire: EC/H2020/760921/EU//PANBioRA
dc.description.abstractScaffolds for articular cartilage repair have to be optimally biodegradable with simultaneous promotion of hyaline cartilage formation under rather complex biomechanical and physiological conditions. It has been generally accepted that scaffold structure and composition would be the best when it mimics the structure of native cartilage. However, a reparative construct mimicking the mature native tissue in a healing tissue site presents a biological mismatch of reparative stimuli. In this work, we studied a new recombinant human type III collagen-polylactide (rhCol-PLA) scaffolds. The rhCol-PLA scaffolds were assessed for their relative performance in simulated synovial fluids of 1 and 4 mg/mL sodium hyaluronate with application of model-free analysis with Biomaterials Enhanced Simulation Test (BEST). Pure PLA scaffold was used as a control. The BEST results were compared to the results of a prior in vivo study with rhCol-PLA. Collectively the data indicated that a successful articular cartilage repair requirelower stiffness of the scaffold compared to surrounding cartilage yet matching the strain compliance both in static and dynamic conditions. This ensures an optimal combination of load transfer and effective oscillatory nutrients supply to the cells. The results encourage further development of intelligent scaffold structures for optimal articular cartilage repair rather than simply trying to imitate the respective original tissue.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdf
dc.identifier.citationGasik , M , Zühlke , A , Haaparanta , A-M , Muhonen , V , Laine , K , Bilotsky , Y , Kellomäki , M & Kiviranta , I 2018 , ' The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration ' , Frontiers in Bioengineering and Biotechnology . https://doi.org/10.3389/fbioe.2018.00187en
dc.identifier.doi10.3389/fbioe.2018.00187
dc.identifier.otherPURE UUID: 8ad50bf9-cdcd-4e5a-8457-958a4249b0b5
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/8ad50bf9-cdcd-4e5a-8457-958a4249b0b5
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/30224685/CHEM_Gasik_et_al_The_importance_of_2018_Frontiers_in_Bioengineering_and_Biotechnology.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/35145
dc.identifier.urnURN:NBN:fi:aalto-201812106160
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/760921/EU//PANBioRA
dc.relation.ispartofseriesFRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGYen
dc.rightsopenAccessen
dc.titleThe Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regenerationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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