Quaternized phthalocyanines as a tool against melanoma and a broad spectrum of bacteria and fungi

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Authors

Date

2025-07

Department

Department of Bioproducts and Biosystems

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Mcode

Degree programme

Language

en

Pages

12

Series

Journal of Photochemistry and Photobiology B: Biology, Volume 268

Abstract

Photodynamic therapy can be a powerful tool to combat two of the greatest challenges of 21st-century medicine – antibiotic-resistant infections and cancer. Each of these factors claims millions of human lives annually. In the presented study, a wide variety of cationic phthalocyanines was tested against selected pathogens: Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Escherichia coli producing extended-spectrum β-lactamases, Pseudomonas aeruginosa, carbapenem resistant Pseudomonas aeruginosa, Trichophyton mentagrophytes, Candida albicans. The compounds used in this study, which are functionalized with pyridyloxy substituents and in some cases bear bulky substituents (tert-butylphenyl or pyrenyl moieties) at the 5th position of the pyridyloxy ring, proved to be remarkably effective against all pathogens, allowing for a reduction in the number of microorganisms between 1.4 and 5.6 logs. Additionally, coaction with the commonly used antibiotic – doxycycline – was achieved in in vitro studies. The effectiveness of these macrocycles was also evaluated against melanoma cells (MICH2), showing a significant reduction in melanoma cell viability up to 85 %. Therefore, the investigated compounds can be considered as promising photosensitizers in modern photodynamic therapy.

Description

Publisher Copyright: © 2025 The Authors

Keywords

Antibiotic resistance, Doxycycline, Melanoma, PACT, PDT, Phthalocyanines

Other note

DOI

10.1016/j.jphotobiol.2025.113187

Citation

Ziental, D, Anaya-Plaza, E, Talarska-Kulczyk, P, Kubicka, A, Żurawski, J, Dlugaszewska, J, de la Escosura, A, Torres, T & Sobotta, L 2025, 'Quaternized phthalocyanines as a tool against melanoma and a broad spectrum of bacteria and fungi', Journal of Photochemistry and Photobiology B: Biology, vol. 268, 113187. https://doi.org/10.1016/j.jphotobiol.2025.113187

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https://urn.fi/URN:NBN:fi:aalto-202506265304

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[article-cris] Kemian tekniikan korkeakoulu / CHEM