Feasibility of 3D-printed middle ear prostheses in partial ossicular chain reconstruction
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2023
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Language
en
Pages
12
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International Journal of Bioprinting, Volume 9, issue 4
Abstract
Despite advances in prosthesis materials, operating microscopes and surgical techniques during the last 50 years, long-lasting hearing improvement remains a challenge in ossicular chain reconstruction. Failures in the reconstruction are mainly due to inadequate length or shape of the prosthesis, or defects in the surgical procedure. 3D-printed middle ear prosthesis might offer a solution to individualize treatment and obtain better results. The aim of the study was to study the possibilities and limitations of 3D-printed middle ear prostheses. Design of the 3D-printed prosthesis was inspired by a commercial titanium partial ossicular replacement prosthesis. 3D models of different lengths (1.5–3.0 mm) were created with Solidworks 2019–2021 software. The prostheses were 3D-printed with vat photopolymerization using liquid photopolymer Clear V4. Accuracy and reproducibility of 3D printing were evaluated with micro-CT imaging. The acoustical performance of the prostheses was determined in cadaver temporal bones with laser Doppler vibrometry. In this paper, we present an outline of individualized middle ear prosthesis manufacturing. 3D printing accuracy was excellent when comparing dimensions of the 3D-printed prostheses and their 3D models. Reproducibility of 3D printing was good if the diameter of the prosthesis shaft was 0.6 mm. 3D-printed partial ossicular replacement prostheses were easy to manipulate during surgery even though they were a bit stiffer and less flexible than conventional titanium prostheses. Their acoustical performance was similar to that of a commercial titanium partial ossicular replacement prosthesis. It is possible to 3D print functional individualized middle ear prostheses made of liquid photopolymer with good accuracy and reproducibility. These prostheses are currently suitable for otosurgical training. Further research is needed to explore their usability in a clinical setting. In the future, 3D printing of individualized middle ear prostheses may provide better audiological outcomes for patients.Description
Funding Information: We want to thank M.Sc. (Tech) Pekka Paavola for photo stacking technique photographing. We also want to thank Ph.D. Jukka Kuva (Geological Survey of Finland, Espoo, Finland) for collaboration with regard to micro-CT imaging. X-ray tomography was supported by the Academy of Finland via RAMI infrastructure project (#293109). Funding Information: This study has been funded by the Tauno Palva Foundation, the Helsinki University Hospital Research Fund and the Academy of Finland Grant 325509. Publisher Copyright: © 2023 Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution License, permitting distribution and reproduction in any medium, provided the original work is properly cited.
Keywords
3D printing, Laser Doppler vibrometry, Middle ear transfer function, Ossicular chain reconstruction, Partial ossicular replacement prosthesis, Total ossicular replacement prosthesis
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Citation
Heikkinen, A K, Lähde, S, Rissanen, V, Salmi, M, Aarnisalo, A A, Mäkitie, A, Sivonen, V & Sinkkonen, S T 2023, ' Feasibility of 3D-printed middle ear prostheses in partial ossicular chain reconstruction ', International Journal of Bioprinting, vol. 9, no. 4 . https://doi.org/10.18063/ijb.727