Ultrasonic actuation of a fine-needle improves biopsy yield

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorPerra, Emanueleen_US
dc.contributor.authorLampsijärvi, Eetuen_US
dc.contributor.authorBarreto, Gonçaloen_US
dc.contributor.authorArif, Muhammaden_US
dc.contributor.authorPuranen, Tuomasen_US
dc.contributor.authorHæggström, Edwarden_US
dc.contributor.authorPritzker, Kenneth P.H.en_US
dc.contributor.authorNieminen, Heikki J.en_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationUniversity of Helsinkien_US
dc.contributor.organizationUniversity of Torontoen_US
dc.date.accessioned2021-05-05T06:18:23Z
dc.date.available2021-05-05T06:18:23Z
dc.date.issued2021-12en_US
dc.descriptionFunding Information: We thank Mr. Matti Mikkola, M.Sc., Mr. Yohann Le Bourlout, M.Sc., Mr. Pauli Tuovinen, B.Sc. Nallannan Bal-asubramanian, Ph.D. and Adjunct Prof. Gösta Ehnholm, Ph.D., for constructive discussions related to the topic, and Dr. Nick Hayward, MBBS, Ph.D. for linguistic review of the manuscript. We thank Jyrki Kreula, MD, Ph.D. for guidance and providing us extensive information related to the FNAB procedure. We also would like to thank Prof. Kari Eklund, MD, Ph.D. for support in histological experimentation. We thank the Tissue Preparation and Histochemistry Unit in the Department of Anatomy, University of Helsinki. Histology images were generated using the 3DHISTECH Pannoramic 250 FLASH II digital slide scanner at Genome Biology Unit supported by HiLIFE and the Faculty of Medicine, University of Helsinki, and BioCenter Finland. The Academy of Finland is acknowledged for financial support (grants 314286 and 311586). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
dc.description.abstractDespite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationPerra, E, Lampsijärvi, E, Barreto, G, Arif, M, Puranen, T, Hæggström, E, Pritzker, K P H & Nieminen, H J 2021, ' Ultrasonic actuation of a fine-needle improves biopsy yield ', Scientific Reports, vol. 11, no. 1, 8234 . https://doi.org/10.1038/s41598-021-87303-xen
dc.identifier.doi10.1038/s41598-021-87303-xen_US
dc.identifier.issn2045-2322
dc.identifier.otherPURE UUID: 6a5879d5-f006-4e59-84a3-26c45f57d0cben_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/6a5879d5-f006-4e59-84a3-26c45f57d0cben_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85104444859&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/62439749/Perra_Ultrasonic.s41598_021_87303_x_1.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/107225
dc.identifier.urnURN:NBN:fi:aalto-202105056489
dc.language.isoenen
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reportsen
dc.relation.ispartofseriesVolume 11, issue 1en
dc.rightsopenAccessen
dc.titleUltrasonic actuation of a fine-needle improves biopsy yielden
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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