Ultrasonic actuation of a fine-needle improves biopsy yield
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2021-12
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en
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Scientific Reports, Volume 11, issue 1
Abstract
Despite the ubiquitous use over the past 150 years, the functions of the current medical needle are facilitated only by mechanical shear and cutting by the needle tip, i.e. the lancet. In this study, we demonstrate how nonlinear ultrasonics (NLU) extends the functionality of the medical needle far beyond its present capability. The NLU actions were found to be localized to the proximity of the needle tip, the SonoLancet, but the effects extend to several millimeters from the physical needle boundary. The observed nonlinear phenomena, transient cavitation, fluid streams, translation of micro- and nanoparticles and atomization, were quantitatively characterized. In the fine-needle biopsy application, the SonoLancet contributed to obtaining tissue cores with an increase in tissue yield by 3–6× in different tissue types compared to conventional needle biopsy technique using the same 21G needle. In conclusion, the SonoLancet could be of interest to several other medical applications, including drug or gene delivery, cell modulation, and minimally invasive surgical procedures.Description
Funding Information: We thank Mr. Matti Mikkola, M.Sc., Mr. Yohann Le Bourlout, M.Sc., Mr. Pauli Tuovinen, B.Sc. Nallannan Bal-asubramanian, Ph.D. and Adjunct Prof. Gösta Ehnholm, Ph.D., for constructive discussions related to the topic, and Dr. Nick Hayward, MBBS, Ph.D. for linguistic review of the manuscript. We thank Jyrki Kreula, MD, Ph.D. for guidance and providing us extensive information related to the FNAB procedure. We also would like to thank Prof. Kari Eklund, MD, Ph.D. for support in histological experimentation. We thank the Tissue Preparation and Histochemistry Unit in the Department of Anatomy, University of Helsinki. Histology images were generated using the 3DHISTECH Pannoramic 250 FLASH II digital slide scanner at Genome Biology Unit supported by HiLIFE and the Faculty of Medicine, University of Helsinki, and BioCenter Finland. The Academy of Finland is acknowledged for financial support (grants 314286 and 311586). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
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Perra, E, Lampsijärvi, E, Barreto, G, Arif, M, Puranen, T, Hæggström, E, Pritzker, K P H & Nieminen, H J 2021, ' Ultrasonic actuation of a fine-needle improves biopsy yield ', Scientific Reports, vol. 11, no. 1, 8234 . https://doi.org/10.1038/s41598-021-87303-x