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High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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10
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Chemical Science, Volume 9, issue 5, pp. 1358-1367
Abstract
Pyrophosphate (PPi) is a byproduct of DNA and RNA synthesis, and abnormal levels are indicative of disease. We report the high-affinity binding of PPi in water by N-alkyl ammonium resorcinarene chloride receptors. Experimental analysis using 1H and 31P NMR, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy all support exceptional selectivity of these systems for PPi in water. The measured affinity of K1 = 1.60 × 107 M-1 for PPi is three orders of magnitude larger than that observed for binding to another phosphate, ATP. This exceptional anion-binding affinity in water is explored through a detailed density functional theory computational study. These systems provide a promising avenue for the development of future innovative medical diagnostic tools.
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Beyeh, N K, Díez, I, Taimoory, S M, Meister, D, Feig, A I, Trant, J F, Ras, R H A & Rissanen, K 2018, 'High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor', Chemical Science, vol. 9, no. 5, pp. 1358-1367. https://doi.org/10.1039/c7sc05167k