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DELMEP : a deep learning algorithm for automated annotation of motor evoked potential latencies
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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11
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Scientific Reports, Volume 13, issue 1, pp. 1-11
Abstract
The analysis of motor evoked potentials (MEPs) generated by transcranial magnetic stimulation (TMS) is crucial in research and clinical medical practice. MEPs are characterized by their latency and the treatment of a single patient may require the characterization of thousands of MEPs. Given the difficulty of developing reliable and accurate algorithms, currently the assessment of MEPs is performed with visual inspection and manual annotation by a medical expert; making it a time-consuming, inaccurate, and error-prone process. In this study, we developed DELMEP, a deep learning-based algorithm to automate the estimation of MEP latency. Our algorithm resulted in a mean absolute error of about 0.5 ms and an accuracy that was practically independent of the MEP amplitude. The low computational cost of the DELMEP algorithm allows employing it in on-the-fly characterization of MEPs for brain-state-dependent and closed-loop brain stimulation protocols. Moreover, its learning ability makes it a particularly promising option for artificial-intelligence-based personalized clinical applications.
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Funding Information: This research has received funding from the Academy of Finland (Decision Nos. 255347, 265680, 294625, 306845, 348631, and 349985), the Finnish Cultural Foundation, Jane and Aatos Erkko Foundation, Erasmus Mundus SMART2 (No. 552042-EM-1-2014-1-FR-ERA MUNDUSEMA2), the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq; grant number 140787/2014-3), the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ConnectToBrain, grant agreement No. 810377), Personalized Health and Related Technologies (PHRT #2017-205) of the ETH Domain, Defitech Foundation and the Wyss Center for Bio and Neuroengineering. | openaire: EC/H2020/810377/EU//ConnectToBrain
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Milardovich, D, Souza, V H, Zubarev, I, Tugin, S, Nieminen, J O, Bigoni, C, Hummel, F C, Korhonen, J T, Aydogan, D B, Lioumis, P, Taherinejad, N, Grasser, T & Ilmoniemi, R J 2023, 'DELMEP : a deep learning algorithm for automated annotation of motor evoked potential latencies', Scientific Reports, vol. 13, no. 1, 8225, pp. 1-11. https://doi.org/10.1038/s41598-023-34801-9