Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation

dc.contributorAalto Universityen
dc.contributor.authorVergara Lourencon, Tainiseen_US
dc.contributor.authorde Lima, Gabriel G.en_US
dc.contributor.authorRibeiro, Carolina S. P.en_US
dc.contributor.authorHansel, Fabrício A.en_US
dc.contributor.authorMaciel, Giselle M.en_US
dc.contributor.authorda Silva, Krisleen_US
dc.contributor.authorWinnischofer, Sheila M. B.en_US
dc.contributor.authorde Muniz, Graciela I. B.en_US
dc.contributor.authorMagalhães, Washington L Een_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorWood Material Scienceen
dc.contributor.organizationFederal University of Paranáen_US
dc.contributor.organizationEmbrapa Florestasen_US
dc.contributor.organizationFederal University of Technologyen_US
dc.contributor.organizationUniversidade Federal do Paranáen_US
dc.description.abstractKraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecular weight distribution and chemical composition heterogeneity led to the development of fractionation methods. Herein, to narrow such characteristics we used eucalypt kraft lignin fractionated at pH's 9, 7, 5 and 3 by sequential acid precipitation. These lignin fractions were first characterised by simultaneous pyrolysis and trimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxidant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increase in antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions precipitated at pH's 9 and 7 have shown an outstanding antibacterial activity against five bacteria. Moreover, fractions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G glioma cells, while only a slight inhibition of adult human fibroblasts (non-tumour cells) was detected.en
dc.description.versionPeer revieweden
dc.identifier.citationVergara Lourencon, T, de Lima, G G, Ribeiro, C S P, Hansel, F A, Maciel, G M, da Silva, K, Winnischofer, S M B, de Muniz, G I B & Magalhães, W L E 2021, ' Antioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitation ', International Journal of Biological Macromolecules, vol. 166, pp. 1535-1542 .
dc.identifier.otherPURE UUID: dff2c43c-e0d4-4c0a-a4d6-101a35b93299en_US
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dc.relation.ispartofseriesInternational Journal of Biological Macromoleculesen
dc.subject.keywordtechnical ligninen_US
dc.subject.keywordradical scavengingen_US
dc.subject.keywordhardwood ligninen_US
dc.titleAntioxidant, antibacterial and antitumoural activities of kraft lignin from hardwood fractionated by acid precipitationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi