Shear Alignment of Bola-Amphiphilic Arginine-Coated Peptide Nanotubes

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorHamley, Ian W.en_US
dc.contributor.authorBurholt, Samuelen_US
dc.contributor.authorHutchinson, Jessicaen_US
dc.contributor.authorCastelletto, Valeriaen_US
dc.contributor.authorda Silva, Emerson Rodrigoen_US
dc.contributor.authorAlves, Wendelen_US
dc.contributor.authorGutfreund, Philippen_US
dc.contributor.authorPorcar, Lionelen_US
dc.contributor.authorDattani, Rajeeven_US
dc.contributor.authorHermida-Merino, Danielen_US
dc.contributor.authorNewby, Gemmaen_US
dc.contributor.authorReza, Mehedien_US
dc.contributor.authorRuokolainen, Janneen_US
dc.contributor.authorStasiak, Joannaen_US
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.groupauthorMolecular Materialsen
dc.contributor.organizationUniversity of Readingen_US
dc.contributor.organizationUniversidade Federal do ABCen_US
dc.contributor.organizationInstitut Laue-Langevinen_US
dc.contributor.organizationEuropean Synchrotron Radiation Facilityen_US
dc.contributor.organizationUniversity of Cambridgeen_US
dc.date.accessioned2017-05-11T09:11:30Z
dc.date.available2017-05-11T09:11:30Z
dc.date.issued2017-01en_US
dc.description.abstractThe bola-amphiphilic arginine-capped peptide RFL4RF self-assembles into nanotubes in aqueous solution. The nanostructure and rheology are probed by in situ simultaneous rheology/small-angle scattering experiments including rheo-SAXS, rheo-SANS, and rheo-GISANS (SAXS: small-angle X-ray scattering, SANS: small-angle neutron scattering, GISANS: grazing incidence small-angle neutron scattering). Nematic alignment of peptide nanotubes under shear is observed at sufficiently high shear rates under steady shear in either Couette or cone-and-plate geometry. The extent of alignment increases with shear rate. A shear plateau is observed in a flow curve measured in the Couette geometry, indicating the presence of shear banding above the shear rate at which significant orientation is observed (0.1-1 s(-1)). The orientation under shear is transient and is lost as soon as shear is stopped. GISANS shows that alignment at the surface of a cone-and-plate cell develops at sufficiently high shear rates, very similar to that observed in the bulk using the Couette geometry. A small isotope effect (comparing H2O/D2O solvents) is noted in the CD spectra indicating increased interpeptide hydrogen bonding in D2O, although this does not influence nanotube self-assembly. These results provide new insights into the controlled alignment of peptide nanotubes for future applications.en
dc.description.versionPeer revieweden
dc.format.extent9
dc.format.extent141-149
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationHamley, I W, Burholt, S, Hutchinson, J, Castelletto, V, da Silva, E R, Alves, W, Gutfreund, P, Porcar, L, Dattani, R, Hermida-Merino, D, Newby, G, Reza, M, Ruokolainen, J & Stasiak, J 2017, ' Shear Alignment of Bola-Amphiphilic Arginine-Coated Peptide Nanotubes ', Biomacromolecules, vol. 18, no. 1, pp. 141-149 . https://doi.org/10.1021/acs.biomac.6b01425en
dc.identifier.doi10.1021/acs.biomac.6b01425en_US
dc.identifier.issn1525-7797
dc.identifier.issn1526-4602
dc.identifier.otherPURE UUID: ec87f524-3117-4c3d-a96c-8eed6dee3360en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/ec87f524-3117-4c3d-a96c-8eed6dee3360en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/11519861/acs.biomac.6b01425.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/25947
dc.identifier.urnURN:NBN:fi:aalto-201705114322
dc.language.isoenen
dc.relation.ispartofseriesBiomacromoleculesen
dc.relation.ispartofseriesVolume 18, issue 1en
dc.rightsopenAccessen
dc.subject.keywordBOLAAMPHIPHILEen_US
dc.subject.keywordASSEMBLIESen_US
dc.subject.keywordMICROTUBESen_US
dc.subject.keywordTRANSITIONen_US
dc.subject.keywordSURFACESen_US
dc.subject.keywordSOLVENTen_US
dc.subject.keywordCULTUREen_US
dc.subject.keywordFLOWen_US
dc.titleShear Alignment of Bola-Amphiphilic Arginine-Coated Peptide Nanotubesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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