Allometry in the corpus callosum in neonates: Sexual dimorphism
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2022-10-15
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Language
en
Pages
11
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Human Brain Mapping, Volume 43, issue 15, pp. 4609-4619
Abstract
The corpus callosum (CC) is the largest fiber tract in the human brain, allowing interhemispheric communication by connecting homologous areas of the two cerebral hemispheres. In adults, CC size shows a robust allometric relationship with brain size, with larger brains having larger callosa, but smaller brains having larger callosa relative to brain size. Such an allometric relationship has been shown in both males and females, with no significant difference between the sexes. But there is some evidence that there are alterations in these allometric relationships during development. However, it is currently not known whether there is sexual dimorphism in these allometric relationships from birth, or if it only develops later. We study this in neonate data. Our results indicate that there are already sex differences in these allometric relationships in neonates: male neonates show the adult-like allometric relationship between CC size and brain size; however female neonates show a significantly more positive allometry between CC size and brain size than either male neonates or female adults. The underlying cause of this sexual dimorphism is unclear; but the existence of this sexual dimorphism in neonates suggests that sex-differences in lateralization have prenatal origins.Description
Funding Information: Academy of Finland, Grant/Award Numbers: 134950, 1350941, 253270, 253346, 264363, 308176; Hospital District of Southwest Finland State Research Grant, Grant/Award Numbers: K3562, P3003, P3006, P3498, P3654; NARSAD Brain and Behavior Research Foundation, Grant/Award Number: 1956; Yrjö Jahnssonin Säätiö, Grant/Award Number: 6847 Funding Information: This work was supported by the Academy of Finland (grant numbers 264363, 253270, 134950 to Hasse Karlsson; grant numbers 1350941 and 253346 to TP; grant number 308176 to Linnea Karlsson), the Jane and Aatos Erkko Foundation (to Hasse Karlsson), the Varsinais‐Suomen Sairaanhoitopiiri State Research Grants (grant number P3006 to Jetro J Tuulari, grant number P3003 to Noora M. Scheinin, grant number P3498 to Hasse Karlsson, grant number P3654 to Linnea Karlsson, K3562 to Riitta Parkkola), the Signe and Ane Gyllenberg Foundation (to Hasse Karlsson, Noora M. Scheinin and Linnea Karlsson), the Yrjö Jahnssonin Säätiö (grant number 6847 to Linnea Karlsson), the Alfred Kordellin Foundation (to Jetro J Tuulari), the Turku University Foundation (to Jetro J Tuulari), the Emil Aaltosen Säätiö (to Jetro J Tuulari), the Maire Taponen Foundation (to Satu J Lehtola), the Juho Vainio Foundation (to Satu J Lehtola), the Sigrid Jusélius Foundation (to Jetro J Tuulari), the NARSAD Brain and Behavior Research Foundation (grant number 1956 to Linnea Karlsson), the Foundation for Pediatric Research (to Riitta Parkkola), the Canadian Institutes of Health Research (to Vladimir S. Fonov and D. Louis Collins) and the Natural Sciences and Engineering Research Council of Canada (to D. Louis Collins). The research also benefited from computational resources provided by Compute Canada ( www.computecanada.ca ) and Calcul Quebec ( www.calculquebec.ca ). Publisher Copyright: © 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Keywords
brain size, interhemispheric connectivity, lateralization, sex
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Citation
Lewis, J D, Acosta, H, Tuulari, J J, Fonov, V S, Collins, D L, Scheinin, N M, Lehtola, S J, Rosberg, A, Lidauer, K, Ukharova, E, Saunavaara, J, Parkkola, R, Lähdesmäki, T, Karlsson, L & Karlsson, H 2022, ' Allometry in the corpus callosum in neonates: Sexual dimorphism ', Human Brain Mapping, vol. 43, no. 15, pp. 4609-4619 . https://doi.org/10.1002/hbm.25977