Anticancer therapeutic efficacy of biogenic Am-ZnO nanoparticles on 2D and 3D tumor models

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date

2021-12

Department

Department of Applied Physics
Department of Bioproducts and Biosystems

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Mcode

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Language

en

Pages

12

Series

Materials Today Chemistry, Volume 22

Abstract

The present study fabricates biogenic zinc oxide nanoparticles (ZnO NPs) with the aqueous leaf extract of Annona muricata (Am) plant collected from semi-evergreen forests of Odisha, India. The synthesized Am-ZnO NPs were physicochemically characterized. The ultraviolet/visible spectrum showed the maximum optical absorbance of Am-ZnO NPs at 355 nm. High-resolution transmission electron microscopy analysis presented the nearly spherical shape of Am-ZnO NPs with an average particle size of 80 nm. The net surface charge and hydrodynamic size of Am-ZnO NPs were measured to be ∼−2.59 mV and ∼417 nm, respectively. Am-ZnO NPs were found to be biocompatible and hemocompatible nature. Furthermore, Am-ZnO NPs displayed strong anticancer effects on both 2D and 3D tumor models. We observed a dose-dependent toxicity on both A549 and MOLT4 cells and observed a size reduction in the A549 tumor spheroids. Subsequently, we observed a depolarization in mitochondrial membrane potential of Am-ZnO NP–treated cancer cells leading to the apoptosis induction in cancer cells.

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Keywords

ZnO, Nanoparticles, Anti-cancer, Apoptosis, Leaf's extract, Annona muricata, ZINC-OXIDE NANOPARTICLES, GREEN SYNTHESIS, LEAF EXTRACT, METAL, BIOSYNTHESIS, ANTIOXIDANT, BACTERIA, DELIVERY

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DOI

10.1016/j.mtchem.2021.100618

Citation

Chabattula, S C, Gupta, P K, Tripathi, S K, Gahtori, R, Padhi, P, Mahapatra, S, Biswal, B K, Singh, S K, Dua, K, Ruokolainen, J, Mishra, Y K, Jha, N K, Bishi, D K & Kesari, K K 2021, 'Anticancer therapeutic efficacy of biogenic Am-ZnO nanoparticles on 2D and 3D tumor models', Materials Today Chemistry, vol. 22, 100618. https://doi.org/10.1016/j.mtchem.2021.100618

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https://urn.fi/URN:NBN:fi:aalto-2021121510741

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[article-cris] Kemian tekniikan korkeakoulu / CHEM