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Antimicrobial efficacy of solar disinfection in cellulose fiber supported photoactive materials
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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8
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Materials Today Communications, Volume 38
Abstract
According to the World Health Organization, antimicrobial resistance is one of the emerging threats to global health. Therefore, the development of new strategies to mitigate resistant bacterial strains is highly desirable. Photodynamic inactivation is a promising approach owing to its effectiveness against a broad range of microorganisms irrespective of their antibiotic resistance profile and its multitarget mechanism that hamper the appearance of acquired resistance. In this work, a self-sterilizing and potentially biodegradable material is developed, providing a green alternative for single-use packaging in the medical, food, and cosmetic industry. We demonstrate two synthetic approaches based on covalent linkage of toluidine blue to tempo-oxidized carbon nanofibers, as well as the supramolecular immobilization based on electrostatic self-assembly. The former shows high activity, reaching inactivation rates of 8 Log10 CFU for S. aureus and E. coli after 15 min under 250 W·m−2 artificial sun irradiation. This simple and facile approach will enable the preparation of composite photoantimicrobial films that are light activated, providing clean and microbiologically safe surfaces, even in challenging situations, such as natural disasters or conflicts, or remote locations with of none or limited access to other forms of energy supply.
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Funding Information: This work was a part of the Academy of Finland's Flagship Programme under Projects No. 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES), the Magnus Ehrnrooth foundation, the Academy of Finland (341057), and the Academy of Finland Centers of Excellence Program (2022– 2029) in Life-Inspired Hybrid Materials (LIBER). We acknowledge the provision of facilities and technical support by Aalto University Bioeconomy Facilities and OtaNano – Nanomicroscopy Center (Aalto-NMC). This research was funded by the Spanish Agencia Estatal de Investigación and FEDER (grant number PID2020-115801RB-C22 and RYC2021-032773-I) and AGAUR (2020BP00066). S.N. thanks the Departament de Recerca i Universitats de la Generalitat de Catalunya for the support given to our research group (2021 SGR 01023) and the ICREA—Catalan Institution for Research and Advanced Studies for grant No. Ac2232308. The preparation and synthesis of the TOCNF, 1 and 2, the purification of those materials, the quantum yield, the PDI assay with its additional graphs are included in the Supporting Information. Publisher Copyright: © 2023 The Authors
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Langerreiter, D, Solin, K, Jordà-Redondo, M, Bresolí-Obach, R, Fliri, L, Nonell, S, Kostiainen, M A & Anaya-Plaza, E 2024, 'Antimicrobial efficacy of solar disinfection in cellulose fiber supported photoactive materials', Materials Today Communications, vol. 38, 107858. https://doi.org/10.1016/j.mtcomm.2023.107858