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Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan
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en
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18
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Human Brain Mapping, Volume 47, issue 4, pp. 1-18
Abstract
The operation of the human brain relies on functional networks enabled by inter-areal oscillatory synchronization between neuronal populations. Although disruptions in this functional connectivity are associated with brain disorders, evidence on its healthy age-dependent variation and behavioral relevance remains limited. Utilizing magnetoencephalography (MEG) recordings from 576 adults aged 18–87 years, we investigated the evolution of resting-state functional connectivity (rs-FC) across the healthy adult lifespan. We observed age-related, frequency-specific changes in widespread cortical networks. Alpha-band (8–13 Hz) rs-FC decreased, while delta (1–4 Hz), theta (4–8 Hz), and gamma-band (40–90 Hz) rs-FC increased with age. Beta-band (13–30 Hz) rs-FC followed a non-linear trajectory, peaking in middle age. The global delta, theta, alpha, and beta-band patterns differed from concurrent changes in oscillatory power, underscoring their dissociable contributions. Notably, reduced beta-band rs-FC was associated with increased sensorimotor attenuation, indicating that changes in rs-FC are behaviorally relevant for sensorimotor function. These findings advance our understanding of healthy brain aging and highlight a link between resting-state brain activity and sensorimotor integration.
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Publisher Copyright: © 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC.
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Ruuskanen, S, Avendano-Diaz, J C, Liljeström, M & Parkkonen, L 2026, 'Frequency-Resolved Cortical Functional Connectivity Across the Adult Lifespan', Human Brain Mapping, vol. 47, no. 4, e70484, pp. 1-18. https://doi.org/10.1002/hbm.70484