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Transcranial magnetic stimulation set-up for small animals
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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Frontiers in Neuroscience, Volume 16
Abstract
Transcranial magnetic stimulation (TMS) is widely applied on humans for research and clinical purposes. TMS studies on small animals, e.g., rodents, can provide valuable knowledge of the underlying neurophysiological mechanisms. Administering TMS on small animals is, however, prone to technical difficulties, mainly due to their small head size. In this study, we aimed to develop an energy-efficient coil and a compatible experimental set-up for administering TMS on rodents. We applied a convex optimization process to develop a minimum-energy coil for TMS on rats. As the coil windings of the optimized coil extend to a wide region, we designed and manufactured a holder on which the rat lies upside down, with its head supported by the coil. We used the set-up to record TMS–electromyography, with electromyography recorded from limb muscles with intramuscular electrodes. The upside-down placement of the rat allowed the operator to easily navigate the TMS without the coil blocking their field of view. With this paradigm, we obtained consistent motor evoked potentials from all tested animals.
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Funding Information: This project had received funding from the Academy of Finland (Decision Nos. 265680, 294625, 306845, 308265, and 341361) and EraNet Neuron ACROBAT. Publisher Copyright: Copyright © 2022 Nieminen, Pospelov, Koponen, Yrjölä, Shulga, Khirug and Rivera.
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Nieminen, J O, Pospelov, A S, Koponen, L M, Yrjölä, P, Shulga, A, Khirug, S & Rivera, C 2022, 'Transcranial magnetic stimulation set-up for small animals', Frontiers in Neuroscience, vol. 16, 935268. https://doi.org/10.3389/fnins.2022.935268