Lack of Cortical Correlates of Response Inhibition in 6-Year-Olds Born Extremely Preterm - Evidence from a Go/NoGo Task in Magnetoencephalographic Recordings
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Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2017-01-06
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Mcode
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Language
en
Pages
12
Series
FRONTIERS IN HUMAN NEUROSCIENCE, Volume 10
Abstract
Children born extremely preterm (EPT) may have difficulties in response inhibition, but the neural basis of such problems is unknown. We recorded magnetoencephalography (MEG) during a somatosensory Go/NoGo task in 6-year-old children born EPT (n = 22) and in children born full term (FT; n = 21). The children received tactile stimuli randomly to their left little (target) and index (non-target) finger and were instructed to squeeze a soft toy with the opposite hand every time they felt a stimulus on the little finger. Behaviorally, the EPT children performed worse than the FT children, both in responding to the target finger stimulation and in refraining from responding to the non-target finger stimulation. In MEG, after the non-target finger stimulation (i.e., during the response inhibition), the sensorimotor alpha oscillation levels in the contralateral-to-squeeze hemisphere were elevated in the FT children when compared with a condition with corresponding stimulation but no task (instead the children were listening to a story and not attending to the fingers). This NoGo task effect was absent in the EPT children. Further, in the sensorimotor cortex contralateral to the tactile stimulation, the post stimulus suppression was less pronounced in the EPT than FT children. We suggest that the missing NoGo task effect and lower suppression of sensorimotor oscillations are markers of deficient functioning of the sensorimotor networks in the EPT children.Description
Keywords
children, preterm, magnetoencephalography (MEG), oscillations, response inhibition, somatosensory, LOW-BIRTH-WEIGHT, EXECUTIVE FUNCTIONS, GESTATIONAL-AGE, CHILDREN BORN, MU-RHYTHM, ALPHA OSCILLATIONS, WORKING-MEMORY, MRI TEMPLATES, GO TASKS, ATTENTION
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Citation
Pihko , E , Lönnberg , P , Lauronen , L , Wolford , E , Andersson , S , Lano , A , Metsäranta , M & Nevalainen , P 2017 , ' Lack of Cortical Correlates of Response Inhibition in 6-Year-Olds Born Extremely Preterm - Evidence from a Go/NoGo Task in Magnetoencephalographic Recordings ' , FRONTIERS IN HUMAN NEUROSCIENCE , vol. 10 , 666 . https://doi.org/10.3389/fnhum.2016.00666
