Neurotoxicity of pesticides – A link to neurodegeneration
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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en
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11
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Ecotoxicology and Environmental Safety, Volume 243, pp. 1-11
Abstract
Parkinson's disease (PD) is a neurodegenerative disorder which mainly targets motor symptoms such as tremor, rigidity, bradykinesia and postural instability. The physiological changes occur due to dopamine depletion in basal ganglia region of the brain. PD aetiology is not yet elucidated clearly but genetic and environmental factors play a prominent role in disease occurrence. Despite of various environmental factors, pesticides exposure has been convicted as major candidate in PD pathogenesis. Among various pesticides 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) has been widely investigated in PD following with paraquat (PQ), maneb (MB), organochlorines (OC) and rotenone. Effect of these pesticides has been suggested to be involved in oxidative stress, alterations in dopamine transporters, mitochondrial dysfunction, α-synuclein (αSyn) fibrillation, and neuroinflammation in PD. The present review discusses the influence of pesticides in neurodegeneration and its related epidemiological studies conducted in PD. Furthermore, we have deliberated the common pesticides involved in PD and its associated genetic alterations and the probable mechanism of them behind PD pathogenesis. Hence, we conclude that pesticides play a prominent role in PD pathogenesis and advance research is needed to investigate the alterations in genetic and mechanistic aspects of PD.Description
Funding Information: The author Dr. VB would like to thank Bharathiar University for providing the necessary infrastructure facility and the Indian Council of Medical Research DHR-GIA [grant number: GIA/2019/000276/PRCGIA], Government of India, New Delhi for providing necessary help in carrying out this review process. Funding Information: This work was supported by the Indian Council of Medical Research DHR-GIA [grant number: GIA/2019/000276/PRCGIA ], and by the Department of Applied Physics, School of Science, Aalto University , Espoo, Finland. Government of India. Publisher Copyright: © 2022
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Vellingiri, B, Chandrasekhar, M, Sri Sabari, S, Gopalakrishnan, A V, Narayanasamy, A, Venkatesan, D, Iyer, M, Kesari, K & Dey, A 2022, 'Neurotoxicity of pesticides – A link to neurodegeneration', Ecotoxicology and Environmental Safety, vol. 243, 113972, pp. 1-11. https://doi.org/10.1016/j.ecoenv.2022.113972