Engineered protein cages for selective heparin encapsulation
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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5
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Journal of Materials Chemistry. B, Volume 9, issue 5, pp. 1272-1276
Abstract
A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.Description
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Välimäki, S, Liu, Q, Schoonen, L, F. M. Vervoort, D, Nonappa, N, Linko, V, Nolte, R J M, C. M. van Hest, J & Kostiainen, M 2021, 'Engineered protein cages for selective heparin encapsulation', Journal of Materials Chemistry. B, vol. 9, no. 5, pp. 1272-1276. https://doi.org/10.1039/D0TB02541K