Fusion Dynamics of Hybrid Cell–Microparticle Aggregates
Loading...
Access rights
openAccess
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
Other link related to publication (opens in new window)
View publication in the Research portal (opens in new window)
Other link related to publication (opens in new window)
Date
Major/Subject
Mcode
Degree programme
Language
en
Pages
Series
Langmuir
Abstract
We study the fusion of homogeneous cell aggregates and of hybrid aggregates combining cells and microparticles. In all cases, we find that the contact area does not vary linearly over time, as observed for liquid drops, but rather it follows a power law in t2/3. This result is interpreted by generalizing the fusion model of soft viscoelastic solid balls to viscoelastic liquid balls, akin to jelly pearls. We also explore the asymmetric fusion between a homogeneous aggregate and a hybrid aggregate. This latter experiment allows the determination of the self-diffusion coefficient of the cells in a tissue by following the spatial distribution of internalized particles in the cells.Description
Funding Information: This work was supported by the Academy of Finland Center of Excellence Programme (2014–2019). Publisher Copyright: © 2022 American Chemical Society
Keywords
Other note
Citation
Beaune , G , Sinkkonen , L , Gonzalez-Rodriguez , D , Timonen , J V I & Brochard-Wyart , F 2022 , ' Fusion Dynamics of Hybrid Cell–Microparticle Aggregates : A Jelly Pearl Model ' , Langmuir , vol. 38 , no. 17 , pp. 5296–5306 . https://doi.org/10.1021/acs.langmuir.1c02949