Cortical thinning of parahippocampal subregions in very early Alzheimer's disease

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKrumm, Sabine
dc.contributor.authorKivisaari, Sasa L.
dc.contributor.authorProbst, Alphonse
dc.contributor.authorMonsch, Andreas U.
dc.contributor.authorReinhardt, Julia
dc.contributor.authorUlmer, Stephan
dc.contributor.authorStippich, Christoph
dc.contributor.authorKressig, Reto W.
dc.contributor.authorTaylor, Kirsten I.
dc.contributor.departmentFelix-Platter Hospital
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.contributor.departmentUniversity Hospital Basel
dc.contributor.departmentUniversity Hospital Schleswig-Holstein
dc.contributor.departmentUniversity of Basel
dc.date.accessioned2017-03-28T12:11:55Z
dc.date.available2017-03-28T12:11:55Z
dc.date.issued2016
dc.description.abstractThe stereotypical pattern of neurofibrillary tangle spreading in the earliest stages of typical Alzheimer's dementia (AD) predicts that medial perirhinal cortex (mPRC) atrophy precedes entorhinal cortex (ERC) atrophy, whereas the status of the parahippocampal cortex (PHC) remains unclear. Atrophy studies have focused on more advanced rather than early AD patients, and usually segment the entire PRC as opposed to the mPRC versus lateral PRC (lPRC). The present study therefore determined the extent of ERC, mPRC, lPRC, and PHC atrophy in very early AD (mean Mini-Mental State Examination score = 26) patients and its presumed prodrome amnestic mild cognitive impairment (mean Mini-Mental State Examination score = 28) compared to demographically matched controls. PHG structures were manually segmented (blinded rater) and cortical thicknesses extracted. ERC and mPRC were similarly atrophied in both patient groups. The lPRC was atrophied in the AD group only. Thus, atrophic changes in very early AD broadly map onto the pattern of neurofibrillary tangle spreading and suggest that mPRC, ERC, and lPRC, but not PHC-associated functional impairments, characterize very early-stage AD.en
dc.description.versionPeer revieweden
dc.format.extent9
dc.format.extent188-196
dc.format.mimetypeapplication/pdf
dc.identifier.citationKrumm , S , Kivisaari , S L , Probst , A , Monsch , A U , Reinhardt , J , Ulmer , S , Stippich , C , Kressig , R W & Taylor , K I 2016 , ' Cortical thinning of parahippocampal subregions in very early Alzheimer's disease ' , NEUROBIOLOGY OF AGING , vol. 38 , pp. 188-196 . https://doi.org/10.1016/j.neurobiolaging.2015.11.001en
dc.identifier.doi10.1016/j.neurobiolaging.2015.11.001
dc.identifier.issn0197-4580
dc.identifier.otherPURE UUID: 5b09eadd-abf4-47b4-8a90-bfca40db9152
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/5b09eadd-abf4-47b4-8a90-bfca40db9152
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=84962269925&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/11425723/1_s2.0_S0197458015005539_main.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/25000
dc.identifier.urnURN:NBN:fi:aalto-201703283239
dc.language.isoenen
dc.relation.ispartofseriesNEUROBIOLOGY OF AGINGen
dc.relation.ispartofseriesVolume 38en
dc.rightsopenAccessen
dc.subject.keywordPerirhinal cortex
dc.subject.keywordEntorhinal cortex
dc.subject.keywordParahippocampal cortex
dc.subject.keywordAmnestic mild cognitive impairment
dc.subject.keywordAtrophy
dc.subject.keywordStructural MRI
dc.subject.keywordMILD COGNITIVE IMPAIRMENT
dc.subject.keywordHUMAN CEREBRAL-CORTEX
dc.subject.keywordMEDIAL TEMPORAL-LOBE
dc.subject.keywordENTORHINAL CORTEX
dc.subject.keywordPERIRHINAL CORTEX
dc.subject.keywordNEUROFIBRILLARY TANGLES
dc.subject.keywordHUMAN-BRAIN
dc.subject.keywordMRI
dc.subject.keywordTHICKNESS
dc.subject.keywordDECLINE
dc.titleCortical thinning of parahippocampal subregions in very early Alzheimer's diseaseen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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