Cortical thinning of parahippocampal subregions in very early Alzheimer's disease

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openAccess

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Journal Title

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Volume Title

A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Date

2016

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Mcode

Degree programme

Language

en

Pages

9
188-196

Series

NEUROBIOLOGY OF AGING, Volume 38

Abstract

The stereotypical pattern of neurofibrillary tangle spreading in the earliest stages of typical Alzheimer's dementia (AD) predicts that medial perirhinal cortex (mPRC) atrophy precedes entorhinal cortex (ERC) atrophy, whereas the status of the parahippocampal cortex (PHC) remains unclear. Atrophy studies have focused on more advanced rather than early AD patients, and usually segment the entire PRC as opposed to the mPRC versus lateral PRC (lPRC). The present study therefore determined the extent of ERC, mPRC, lPRC, and PHC atrophy in very early AD (mean Mini-Mental State Examination score = 26) patients and its presumed prodrome amnestic mild cognitive impairment (mean Mini-Mental State Examination score = 28) compared to demographically matched controls. PHG structures were manually segmented (blinded rater) and cortical thicknesses extracted. ERC and mPRC were similarly atrophied in both patient groups. The lPRC was atrophied in the AD group only. Thus, atrophic changes in very early AD broadly map onto the pattern of neurofibrillary tangle spreading and suggest that mPRC, ERC, and lPRC, but not PHC-associated functional impairments, characterize very early-stage AD.

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Keywords

Perirhinal cortex, Entorhinal cortex, Parahippocampal cortex, Amnestic mild cognitive impairment, Atrophy, Structural MRI, MILD COGNITIVE IMPAIRMENT, HUMAN CEREBRAL-CORTEX, MEDIAL TEMPORAL-LOBE, ENTORHINAL CORTEX, PERIRHINAL CORTEX, NEUROFIBRILLARY TANGLES, HUMAN-BRAIN, MRI, THICKNESS, DECLINE

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Citation

Krumm, S, Kivisaari, S L, Probst, A, Monsch, A U, Reinhardt, J, Ulmer, S, Stippich, C, Kressig, R W & Taylor, K I 2016, ' Cortical thinning of parahippocampal subregions in very early Alzheimer's disease ', NEUROBIOLOGY OF AGING, vol. 38, pp. 188-196 . https://doi.org/10.1016/j.neurobiolaging.2015.11.001