Cortical thinning of parahippocampal subregions in very early Alzheimer's disease

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2016
Major/Subject
Mcode
Degree programme
Language
en
Pages
9
188-196
Series
NEUROBIOLOGY OF AGING, Volume 38
Abstract
The stereotypical pattern of neurofibrillary tangle spreading in the earliest stages of typical Alzheimer's dementia (AD) predicts that medial perirhinal cortex (mPRC) atrophy precedes entorhinal cortex (ERC) atrophy, whereas the status of the parahippocampal cortex (PHC) remains unclear. Atrophy studies have focused on more advanced rather than early AD patients, and usually segment the entire PRC as opposed to the mPRC versus lateral PRC (lPRC). The present study therefore determined the extent of ERC, mPRC, lPRC, and PHC atrophy in very early AD (mean Mini-Mental State Examination score = 26) patients and its presumed prodrome amnestic mild cognitive impairment (mean Mini-Mental State Examination score = 28) compared to demographically matched controls. PHG structures were manually segmented (blinded rater) and cortical thicknesses extracted. ERC and mPRC were similarly atrophied in both patient groups. The lPRC was atrophied in the AD group only. Thus, atrophic changes in very early AD broadly map onto the pattern of neurofibrillary tangle spreading and suggest that mPRC, ERC, and lPRC, but not PHC-associated functional impairments, characterize very early-stage AD.
Description
Keywords
Perirhinal cortex, Entorhinal cortex, Parahippocampal cortex, Amnestic mild cognitive impairment, Atrophy, Structural MRI, MILD COGNITIVE IMPAIRMENT, HUMAN CEREBRAL-CORTEX, MEDIAL TEMPORAL-LOBE, ENTORHINAL CORTEX, PERIRHINAL CORTEX, NEUROFIBRILLARY TANGLES, HUMAN-BRAIN, MRI, THICKNESS, DECLINE
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Citation
Krumm , S , Kivisaari , S L , Probst , A , Monsch , A U , Reinhardt , J , Ulmer , S , Stippich , C , Kressig , R W & Taylor , K I 2016 , ' Cortical thinning of parahippocampal subregions in very early Alzheimer's disease ' , NEUROBIOLOGY OF AGING , vol. 38 , pp. 188-196 . https://doi.org/10.1016/j.neurobiolaging.2015.11.001