Melinacidin-producing acrostalagmus luteoalbus, a major constituent of mixed mycobiota contaminating insulation material in an outdoor wall

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2021-07
Major/Subject
Mcode
Degree programme
Language
en
Pages
24
Series
Pathogens, Volume 10, issue 7
Abstract
Occupants may complain about indoor air quality in closed spaces where the officially approved standard methods for indoor air quality risk assessment fail to reveal the cause of the problem. This study describes a rare genus not previously detected in Finnish buildings, Acrostalagmus, and its species A. luteoalbus as the major constituents of the mixed microbiota in the wet cork liner from an outdoor wall. Representatives of the genus were also present in the settled dust in offices where occupants suffered from symptoms related to the indoor air. One strain, POB8, was identified as A. luteoalbus by ITS sequencing. The strain produced the immunosuppressive and cytotoxic melinacidins II, III, and IV, as evidenced by mass spectrometry analysis. In addition, the classical toxigenic species indicating water damage, mycoparasitic Trichoderma, Aspergillus section Versicolores, Aspergillus section Circumdati, Aspergillus section Nigri, and Chaetomium spp., were detected in the wet outdoor wall and settled dust fromthe problematic rooms. The offices exhibited no visible signs of microbial growth, and the airborne load of microbial conidia was too low to explain the reported symptoms. In conclusion, we suggest the possible migration of microbial bioactive metabolites from the wet outdoor wall into indoor spaces as a plausible explanation for the reported complaints.
Description
Funding Information: Funding: This research was funded by the Academy of Finland (CleanSchool project, grant number 330150, and TOXICPM, grant number 289161). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
Acrostalagmus luteoalbus, Cork liner, Guttation droplets, Indoor dust, Melinacidin, Mixed mycobiota, Outdoor wall
Other note
Citation
Andersson , M A , Salo , J , Mikkola , R , Marik , T , Kredics , L , Kurnitski , J & Salonen , H 2021 , ' Melinacidin-producing acrostalagmus luteoalbus, a major constituent of mixed mycobiota contaminating insulation material in an outdoor wall ' , Pathogens , vol. 10 , no. 7 , 843 . https://doi.org/10.3390/pathogens10070843