Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorPauls, K.  Amande Men_US
dc.contributor.authorKorsun, Olesiaen_US
dc.contributor.authorNenonen, Jukkaen_US
dc.contributor.authorNurminen, Jussien_US
dc.contributor.authorLiljeström, Miaen_US
dc.contributor.authorKujala, Janen_US
dc.contributor.authorPekkonen, Eeroen_US
dc.contributor.authorRenvall, Hannaen_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationMegin Oyen_US
dc.contributor.organizationUniversity of Helsinkien_US
dc.date.accessioned2022-08-10T08:26:16Z
dc.date.available2022-08-10T08:26:16Z
dc.date.issued2022-08-15en_US
dc.descriptionFunding Information: Amande Pauls was supported by a personal grant from the University of Helsinki . Olesia Korsun was supported by the Päivikki and Sakari Sohlberg Foundation , the Orion Research Foundation , the Finnish Parkinson Foundation and the Finnish Brain Foundation . Mia Liljeström was supported by the Swedish Cultural Foundation in Finland , the Päivikki and Sakari Sohlberg Foundation , and the Finnish Cultural Foundation . Eero Pekkonen was supported by Finnish Government research funding ( TYH- fund ). Hanna Renvall was supported by the Academy of Finland (grant number 321460 ) and Paulo Foundation. Publisher Copyright: © 2022
dc.description.abstractExaggerated subthalamic beta oscillatory activity and increased beta range cortico-subthalamic synchrony have crystallized as the electrophysiological hallmarks of Parkinson's disease. Beta oscillatory activity is not tonic but occurs in ‘bursts’ of transient amplitude increases. In Parkinson's disease, the characteristics of these bursts are altered especially in the basal ganglia. However, beta oscillatory dynamics at the cortical level and how they compare with healthy brain activity is less well studied. We used magnetoencephalography (MEG) to study sensorimotor cortical beta bursting and its modulation by subthalamic deep brain stimulation in Parkinson's disease patients and age-matched healthy controls. We show that the changes in beta bursting amplitude and duration typical of Parkinson's disease can also be observed in the sensorimotor cortex, and that they are modulated by chronic subthalamic deep brain stimulation, which, in turn, is reflected in improved motor function at the behavioural level. In addition to the changes in individual beta bursts, their timing relative to each other was altered in patients compared to controls: bursts were more clustered in untreated Parkinson's disease, occurring in ‘bursts of bursts’, and re-burst probability was higher for longer compared to shorter bursts. During active deep brain stimulation, the beta bursting in patients resembled healthy controls’ data. In summary, both individual bursts’ characteristics and burst patterning are affected in Parkinson's disease, and subthalamic deep brain stimulation normalizes some of these changes to resemble healthy controls’ beta bursting activity, suggesting a non-invasive biomarker for patient and treatment follow-up.en
dc.description.versionPeer revieweden
dc.format.extent11
dc.format.extent1-11
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationPauls, K AM, Korsun, O, Nenonen, J, Nurminen, J, Liljeström, M, Kujala, J, Pekkonen, E & Renvall, H 2022, ' Cortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulation ', NeuroImage, vol. 257, 119308, pp. 1-11 . https://doi.org/10.1016/j.neuroimage.2022.119308en
dc.identifier.doi10.1016/j.neuroimage.2022.119308en_US
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572
dc.identifier.otherPURE UUID: cb3b0d45-927b-4fe5-b4ce-057e130725a0en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/cb3b0d45-927b-4fe5-b4ce-057e130725a0en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85131682184&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/85257766/Cortical_beta_burst_dynamics_are_altered_in_Parkinson_s_disease_but_normalized_by_deep_brain_stimulation.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/115923
dc.identifier.urnURN:NBN:fi:aalto-202208104745
dc.language.isoenen
dc.publisherACADEMIC PRESS
dc.relation.ispartofseriesNeuroImageen
dc.relation.ispartofseriesVolume 257en
dc.rightsopenAccessen
dc.subject.keywordBeta bursten_US
dc.subject.keywordDeep brain stimulationen_US
dc.subject.keywordMagnetoencephalographyen_US
dc.subject.keywordOscillatory activityen_US
dc.subject.keywordParkinson's diseaseen_US
dc.subject.keywordResting stateen_US
dc.titleCortical beta burst dynamics are altered in Parkinson's disease but normalized by deep brain stimulationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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