Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage—study protocol for a randomized clinical trial

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorLaaksonen, Mikaelen_US
dc.contributor.authorRinne, Jaakkoen_US
dc.contributor.authorRahi, Melissaen_US
dc.contributor.authorPosti, Jussi P.en_US
dc.contributor.authorLaitio, Ruuten_US
dc.contributor.authorKivelev, Jurien_US
dc.contributor.authorSaarenpää, Ilkkaen_US
dc.contributor.authorLaukka, Danen_US
dc.contributor.authorFrösen, Juhanaen_US
dc.contributor.authorRonkainen, Anttien_US
dc.contributor.authorBendel, Stepanien_US
dc.contributor.authorLångsjö, Jaakkoen_US
dc.contributor.authorAla-Peijari, Marikaen_US
dc.contributor.authorSaunavaara, Janien_US
dc.contributor.authorParkkola, Riittaen_US
dc.contributor.authorNyman, Mikkoen_US
dc.contributor.authorMartikainen, Ilkka K.en_US
dc.contributor.authorDickens, Alex M.en_US
dc.contributor.authorRinne, Juhaen_US
dc.contributor.authorValtonen, Mikaen_US
dc.contributor.authorSaari, Teijo I.en_US
dc.contributor.authorKoivisto, Timoen_US
dc.contributor.authorBendel, Paulaen_US
dc.contributor.authorRoine, Timoen_US
dc.contributor.authorSaraste, Anttien_US
dc.contributor.authorVahlberg, Teroen_US
dc.contributor.authorTanttari, Juhaen_US
dc.contributor.authorLaitio, Timoen_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationTurku University Hospitalen_US
dc.contributor.organizationTampere Universityen_US
dc.contributor.organizationUniversity of Eastern Finlanden_US
dc.contributor.organizationUniversity of Turkuen_US
dc.contributor.organizationElomatic Indiaen_US
dc.date.accessioned2023-08-01T06:18:27Z
dc.date.available2023-08-01T06:18:27Z
dc.date.issued2023-12en_US
dc.descriptionFunding Information: TL has received funding from the Academy of Finland (# 333010) and from the State Research Funding. ML has received personal research grants from the Finnish Medical Foundation and the Finnish Society of Anaesthesiologists. Publisher Copyright: © 2023, The Author(s).
dc.description.abstractBackground: Aneurysmal subarachnoid hemorrhage (aSAH) is a neurological emergency, affecting a younger population than individuals experiencing an ischemic stroke; aSAH is associated with a high risk of mortality and permanent disability. The noble gas xenon has been shown to possess neuroprotective properties as demonstrated in numerous preclinical animal studies. In addition, a recent study demonstrated that xenon could attenuate a white matter injury after out-of-hospital cardiac arrest. Methods: The study is a prospective, multicenter phase II clinical drug trial. The study design is a single-blind, prospective superiority randomized two-armed parallel follow-up study. The primary objective of the study is to explore the potential neuroprotective effects of inhaled xenon, when administered within 6 h after the onset of symptoms of aSAH. The primary endpoint is the extent of the global white matter injury assessed with magnetic resonance diffusion tensor imaging of the brain. Discussion: Despite improvements in medical technology and advancements in medical science, aSAH mortality and disability rates have remained nearly unchanged for the past 10 years. Therefore, new neuroprotective strategies to attenuate the early and delayed brain injuries after aSAH are needed to reduce morbidity and mortality. Trial registration: ClinicalTrials.gov NCT04696523. Registered on 6 January 2021. EudraCT, EudraCT Number: 2019-001542-17. Registered on 8 July 2020.en
dc.description.versionPeer revieweden
dc.format.extent17
dc.format.extent1-17
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationLaaksonen, M, Rinne, J, Rahi, M, Posti, J P, Laitio, R, Kivelev, J, Saarenpää, I, Laukka, D, Frösen, J, Ronkainen, A, Bendel, S, Långsjö, J, Ala-Peijari, M, Saunavaara, J, Parkkola, R, Nyman, M, Martikainen, I K, Dickens, A M, Rinne, J, Valtonen, M, Saari, T I, Koivisto, T, Bendel, P, Roine, T, Saraste, A, Vahlberg, T, Tanttari, J & Laitio, T 2023, ' Effect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage—study protocol for a randomized clinical trial ', Trials, vol. 24, no. 1, 417, pp. 1-17 . https://doi.org/10.1186/s13063-023-07432-8en
dc.identifier.doi10.1186/s13063-023-07432-8en_US
dc.identifier.issn1745-6215
dc.identifier.otherPURE UUID: 4d0c0e10-207f-4b64-b284-23a0e6e022b9en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/4d0c0e10-207f-4b64-b284-23a0e6e022b9en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85162701721&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/115491272/Effect_of_xenon_on_brain_injury_neurological_outcome_and_survival_in_patients_after_aneurysmal_subarachnoid_hemorrhage_study_protocol_for_a_randomized_clinical_trial.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/122186
dc.identifier.urnURN:NBN:fi:aalto-202308014547
dc.language.isoenen
dc.publisherBioMed Central
dc.relation.ispartofseriesTrialsen
dc.relation.ispartofseriesVolume 24, issue 1en
dc.rightsopenAccessen
dc.subject.keywordAneurysmal subarachnoid hemorrhageen_US
dc.subject.keywordaSAHen_US
dc.subject.keywordNeuroprotectionen_US
dc.subject.keywordRandomized controlled trialen_US
dc.subject.keywordXenonen_US
dc.titleEffect of xenon on brain injury, neurological outcome, and survival in patients after aneurysmal subarachnoid hemorrhage—study protocol for a randomized clinical trialen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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