Sonication methods and motion compensation for magnetic resonance guided high-intensity focused ultrasound

Simple item page
dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKöhler, Max 
dc.contributor.departmentLääketieteellisen tekniikan ja laskennallisen tieteen laitosfi
dc.date.accessioned2012-08-23T11:34:50Z
dc.date.available2012-08-23T11:34:50Z
dc.date.issued2009 
dc.description.abstractHigh-intensity focused ultrasound (HIFU) is an efficient noninvasive therapeutic technique for localized heating of tissues deep within the human body through intact skin. Magnetic resonance imaging (MRI) can provide excellent soft-tissue contrast and can be used for both treatment planning and post-treatment assessment of the induced tissue damage. MRI can also provide temperature sensitive in vivo images via proton resonance frequency shift thermometry. Combined, the use of MRI and HIFU (MR-HIFU) ablation make for a promising therapeutic modality for controlled and noninvasive selective tissue destruction. Sonication strategies, MR thermometry methods, feedback control, and motion compensation for MR-HIFU were developed and evaluated in this thesis. The primary aim of the thesis was to develop a safe and efficient strategy for clinical MR-HIFU ablation. An efficient volumetric method of ablation was achieved by utilizing the phased-array capabilities of the transducer and the inherent heat diffusion of already deposited heat. The induced temperature rise was monitored with rapid multiplane MR thermometry with a volumetric coverage of the heated region. Acquisition and display of temperature images during sonication improved the safety of the therapy. The therapeutic procedure was evaluated in a large animal model and proved to provide a substantial improvement in efficiency as compared to existing methods without compromising safety. The second aim was to improve the reliability of the proposed volumetric sonication strategy. This was achieved with a simple and robust binary feedback algorithm that adjusted the sonication duration of each part of the sonication trajectory based on the temperature rise as obtained by volumetric MR thermometry. The feedback algorithm was evaluated in a large animal model, and was found to reduce the variability in thermal lesion size by approximately 70%. The third aim was to develop a through-plane motion correction method for real-time MR thermometry without disturbing thermometry. This was achieved with a fat-selective navigator. This navigator outperformed the conventional navigator for direct tracking of the kidney under free breathing. The navigator also provided accurate indexing of the look-up-table used to correct the reference phase for MR thermometry of mobile organs. Finally, the combination of through-plane motion correction provided by the fat-selective navigator with existing methods of in-plane motion correction and reference phase correction, allowed for an accurate 3D motion compensation of both MR thermometry and MR-HIFU sonication.en
dc.format.extentVerkkokirja (4099 KB, 118 s.) 
dc.format.mimetypeapplication/pdf 
dc.identifier.isbn978-952-248-199-3 
dc.identifier.isbn978-952-248-198-6 (printed)#8195;
dc.identifier.issn1795-4584 
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/4698
dc.identifier.urnURN:ISBN:978-952-248-199-3 
dc.language.isoenen
dc.publisherTeknillinen korkeakouluen
dc.relation.haspart[Publication 1]: M.O. Köhler, C. Mougenot, B. Quesson, J. Enholm, B. Le Bail, C. Laurent, C.T.W. Moonen, and G.J. Ehnholm. Volumetric HIFU ablation under 3D guidance of rapid MRI thermometry. Medical Physics 2009;36(8):3521-3535.en
dc.relation.haspart[Publication 2]: J.K. Enholm, M.O. Köhler, B. Quesson, C. Mougenot, C.T.W. Moonen, and S.D. Sokka. Improved Volumetric MR-HIFU Ablation by Robust Binary Feedback Control. IEEE Transactions on Biomedical Engineering 2009, In press.en
dc.relation.haspart[Publication 3]: M.O. Köhler, C.T.W. Moonen, and M. Ries. Spectral Selective Pencil-Beam Navigator for Abdominal Imaging. Helsinki University of Technology Publications in Engineering Physics, Report TKK-F-A860.en
dc.relation.haspart[Publication 4]: S. Hey, G. Maclair, B. Denis de Senneville, M. Lepetit-Coiffé, Y. Berber, M.O. Köhler, B. Quesson, C.T.W. Moonen, and M. Ries. Online correction of respiratory-induced field disturbances for continuous MR-thermometry in the breast. Magnetic Resonance in Medicine 2009;61(6):1494-1499.en
dc.relation.haspart[Publication 5]: M. Köhler, G. Maclair, B. Denis de Senneville, C. Moonen, and M. Ries. 3D Navigated Real-Time Thermometry for Abdominal Imaging. In: Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008 (abstract 1226).en
dc.relation.ispartofseriesTKK dissertations, 199en
dc.subject.keywordHIFUen
dc.subject.keywordMR thermometryen
dc.subject.keywordMR-HIFUen
dc.subject.keywordsonicationen
dc.subject.keywordablationen
dc.subject.keywordfeedback controlen
dc.subject.keywordmotion compensationen
dc.subject.otherMedical sciencesen
dc.titleSonication methods and motion compensation for magnetic resonance guided high-intensity focused ultrasounden
dc.typeG5 Artikkeliväitöskirjafi
dc.type.dcmitypetexten
dc.type.ontasotVäitöskirja (artikkeli)fi
dc.type.ontasotDoctoral dissertation (article-based)en
local.aalto.digiauthask
local.aalto.digifolderAalto_67475
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
isbn9789522481993.pdf
Size:
3.91 MB
Format:
Adobe Portable Document Format
Download
Collections
[diss] Perustieteiden korkeakoulu / SCI