Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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11
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ACS Applied Polymer Materials, Volume 3, issue 11, pp. 5536-5546
Abstract
Flexible and easy-to-use microfluidic systems are suitable options for point-of-care diagnostics. Here, we investigate liquid transport in fluidic channels produced by stencil printing on flexible substrates as a reproducible and scalable option for diagnostics and paper-based sensing. Optimal printability and flow profiles were obtained by combining minerals with cellulose fibrils of two different characteristic dimensions, in the nano- and microscales, forming channels with ideal wettability. Biomolecular ligands were easily added by inkjet printing on the channels, which were tested for the simultaneous detection of glucose and proteins. Accurate determination of clinically relevant concentrations was possible from linear calibration, confirming the potential of the introduced paper-based diagnostics. The results indicate the promise of simple but reliable fluidic channels for drug and chemical analyses, chromatographic separation, and quality control.Description
| openaire: EC/H2020/788489/EU//BioELCell | openaire: EC/H2020/760876/EU//INNPAPER Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 760876 (INNPAPER project) and the ERC Advanced Grant Agreement No. 788489, “BioElCell”. This work was a part of the Academy of Finland’s Flagship Programme under Projects Nos. 318890 and 318891 (Competence Center for Materials Bioeconomy, FinnCERES). K.S. acknowledges funding by the Aalto University School of Chemical Engineering doctoral programme. The Canada Excellence Research Chair initiative is gratefully acknowledged (OJR). The authors acknowledge the provision of facilities and technical support by Aalto University at OtaNano, Nanomicroscopy Center (Aalto-NMC). Publisher Copyright: © 2021 The Authors. Published by American Chemical Society.
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Solin, K, Borghei, M, Imani, M, Kämäräinen, T, Kiri, K, Mäkelä, T, Khakalo, A, Orelma, H, Gane, P A C & Rojas, O J 2021, 'Bicomponent Cellulose Fibrils and Minerals Afford Wicking Channels Stencil-Printed on Paper for Rapid and Reliable Fluidic Platforms', ACS Applied Polymer Materials, vol. 3, no. 11, pp. 5536-5546. https://doi.org/10.1021/acsapm.1c00856