Highly Enantioselective Conjugate Addition of Thiols Using Mild Scandium Triflate Catalysis

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2007
Major/Subject
Mcode
Degree programme
Language
en
Pages
5411-5413
Series
JOURNAL OF ORGANIC CHEMISTRY, Volume 72, issue 14
Abstract
A Sc complex of (4S,5S)-diphenyl PYBOX 1 was found to serve as a catalyst for the asymmetric conjugate addition reactions between various thiols and 3-crotonoyl-2-oxazolidinone, affording the corresponding adducts in good yields and high enantioselectivies (up to 92% ee). A new improved method for making (4S,5S)-diphenyl PYBOX is presented.
Description
Keywords
addition, conjugate, Michael, scandium, thiol
Other note
Citation
Abe, A, Sauerland, S & Koskinen, A 2007, ' Highly Enantioselective Conjugate Addition of Thiols Using Mild Scandium Triflate Catalysis ', Journal of Organic Chemistry, vol. 72, no. 14, pp. 5411-5413 . https://doi.org/10.1021/jo070492z