Superhydrophobic blood-repellent surfaces

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorJokinen, Villeen_US
dc.contributor.authorKankuri, Eskoen_US
dc.contributor.authorHoshian, Sashaen_US
dc.contributor.authorFranssila, Samien_US
dc.contributor.authorRas, Robinen_US
dc.contributor.departmentDepartment of Chemistry and Materials Scienceen
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorMicrofabricationen
dc.contributor.groupauthorSoft Matter and Wettingen
dc.contributor.organizationUniversity of Helsinkien_US
dc.date.accessioned2018-05-22T14:36:22Z
dc.date.available2018-05-22T14:36:22Z
dc.date.issued2018-06en_US
dc.description| openaire: EC/H2020/725513/EU//SuperRepel
dc.description.abstractSuperhydrophobic surfaces repel water and, in some cases, other liquids as well. The repellency is caused by topographical features at the nano-/microscale and low surface energy. Blood is a challenging liquid to repel due to its high propensity for activation of intrinsic hemostatic mechanisms, induction of coagulation, and platelet activation upon contact with foreign surfaces. Imbalanced activation of coagulation drives thrombogenesis or formation of blood clots that can occlude the blood flow either on-site or further downstream as emboli, exposing tissues to ischemia and infarction. Blood-repellent superhydrophobic surfaces aim toward reducing the thrombogenicity of surfaces of blood-contacting devices and implants. Several mechanisms that lead to blood repellency are proposed, focusing mainly on platelet antiadhesion. Structured surfaces can: (i) reduce the effective area exposed to platelets, (ii) reduce the adhesion area available to individual platelets, (iii) cause hydrodynamic effects that reduce platelet adhesion, and (iv) reduce or alter protein adsorption in a way that is not conducive to thrombus formation. These mechanisms benefit from the superhydrophobic Cassie state, in which a thin layer of air is trapped between the solid surface and the liquid. The connections between water- and blood repellency are discussed and several recent examples of blood-repellent superhydrophobic surfaces are highlighted.en
dc.description.versionPeer revieweden
dc.format.extent10
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationJokinen, V, Kankuri, E, Hoshian, S, Franssila, S & Ras, R 2018, ' Superhydrophobic blood-repellent surfaces ', Advanced Materials, vol. 30, no. 24, 1705104 . https://doi.org/10.1002/adma.201705104en
dc.identifier.doi10.1002/adma.201705104en_US
dc.identifier.issn0935-9648
dc.identifier.issn1521-4095
dc.identifier.otherPURE UUID: 56a7db51-42e3-4943-ba91-28bc847ab908en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/56a7db51-42e3-4943-ba91-28bc847ab908en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/19769492/Jokinen_et_al_2017_Advanced_Materials.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/30913
dc.identifier.urnURN:NBN:fi:aalto-201805222353
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/725513/EU//SuperRepelen_US
dc.relation.ispartofseriesADVANCED MATERIALSen
dc.relation.ispartofseriesarticlenumber 1705104en
dc.rightsopenAccessen
dc.subject.keywordantithrombogenicen_US
dc.subject.keywordblood-compatibleen_US
dc.subject.keywordblood-repellenten_US
dc.subject.keywordnanostructuresen_US
dc.subject.keywordsuperhydrophobicen_US
dc.titleSuperhydrophobic blood-repellent surfacesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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