Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Date
2022-06-17
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Language
en
Pages
12
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iScience, Volume 25, issue 6
Abstract
Precise genome editing with CRISPR/Cas paves the way for many biochemical, biotechnological, and medical applications, and consequently, it may enable treatment of already known and still-to-be-found genetic diseases. Meanwhile, another rapidly emerging field—structural DNA nanotechnology—provides a customizable and modular platform for accurate positioning of nanoscopic materials, for e.g., biomedical uses. This addressability has just recently been applied in conjunction with the newly developed gene engineering tools to enable impactful, programmable nanotechnological applications. As of yet, self-assembled DNA nanostructures have been mainly employed to enhance and direct the delivery of CRISPR/Cas, but lately the groundwork has also been laid out for other intriguing and complex functions. These recent advances will be described in this perspective.Description
Publisher Copyright: © 2022 The Author(s)
Keywords
Genetics, Nanostructure, Nanotechnology
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Citation
Piskunen, P, Latham, R, West, C E, Castronovo, M & Linko, V 2022, ' Integrating CRISPR/Cas systems with programmable DNA nanostructures for delivery and beyond ', iScience, vol. 25, no. 6, 104389 . https://doi.org/10.1016/j.isci.2022.104389