Compressibility and porosity modulate the mechanical properties of giant gas vesicles

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorAl-Terke, Hedar H.
dc.contributor.authorBeaune, Grégory
dc.contributor.authorJunaid, Muhammad
dc.contributor.authorSeitsonen, Jani
dc.contributor.authorPaananen, Arja
dc.contributor.authorTimonen, Jaakko V.I.
dc.contributor.authorJoensuu, Jussi
dc.contributor.authorBrochard-Wyart, Françoise
dc.contributor.authorRas, Robin H.A.
dc.contributor.departmentSoft Matter and Wetting
dc.contributor.departmentDepartment of Applied Physics
dc.contributor.departmentVTT Technical Research Centre of Finland
dc.contributor.departmentActive Matter
dc.contributor.departmentInstitut Curie
dc.date.accessioned2023-02-20T05:14:47Z
dc.date.available2023-02-20T05:14:47Z
dc.date.issued2023-01-24
dc.descriptionFunding Information: This work was carried out under the Academy of Finland Center of Excellence Program (2022-2029) in Life-Inspired Hybrid Materials (LIBER) (project numbers 346109 and 346112). The authors acknowledge the provision of facilities and technical support by Aalto University at OtaNano Nanomicroscopy Center (Aalto-NMC) and Pascal Hersen for stimulating discussions on gas vesicles. Publisher Copyright: Copyright © 2023 the Author(s).
dc.description.abstractGas vesicles used as contrast agents for noninvasive ultrasound imaging must be formulated to be stable, and their mechanical properties must be assessed. We report here the formation of perfluoro-n-butane microbubbles coated with surface-active proteins that are produced by filamentous fungi (hydrophobin HFBI from Trichoderma reesei). Using pendant drop and pipette aspiration techniques, we show that these giant gas vesicles behave like glassy polymersomes, and we discover novel gas extraction regimes. We develop a model to analyze the micropipette aspiration of these compressible gas vesicles and compare them to incompressible liquid-filled vesicles. We introduce a sealing parameter to characterize the leakage of gas under aspiration through the pores of the protein coating. Utilizing this model, we can determine the elastic dilatation modulus, surface viscosity, and porosity of the membrane. These results demonstrate the engineering potential of protein-coated bubbles for echogenic and therapeutic applications and extend the use of the pipette aspiration technique to compressible and porous systems.en
dc.description.versionPeer revieweden
dc.format.extent12
dc.format.extent1-12
dc.format.mimetypeapplication/pdf
dc.identifier.citationAl-Terke , H H , Beaune , G , Junaid , M , Seitsonen , J , Paananen , A , Timonen , J V I , Joensuu , J , Brochard-Wyart , F & Ras , R H A 2023 , ' Compressibility and porosity modulate the mechanical properties of giant gas vesicles ' , Proceedings of the National Academy of Sciences of the United States of America , vol. 120 , no. 4 , e2211509120 , pp. 1-12 . https://doi.org/10.1073/pnas.2211509120en
dc.identifier.doi10.1073/pnas.2211509120
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490
dc.identifier.otherPURE UUID: ce47bfdf-8613-41e2-9f57-247c642a524f
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/ce47bfdf-8613-41e2-9f57-247c642a524f
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85146407386&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/100216045/Compressibility_and_porosity_modulate_the_mechanical_properties_of_giant_gas_vesicles.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/119804
dc.identifier.urnURN:NBN:fi:aalto-202302202151
dc.language.isoenen
dc.publisherNATL ACAD SCIENCES
dc.relation.ispartofseriesProceedings of the National Academy of Sciences of the United States of Americaen
dc.relation.ispartofseriesVolume 120, issue 4en
dc.rightsopenAccessen
dc.subject.keywordbubbles
dc.subject.keywordcompressibility
dc.subject.keywordgas vesicles
dc.subject.keywordporosity
dc.subject.keywordviscoelasticity
dc.titleCompressibility and porosity modulate the mechanical properties of giant gas vesiclesen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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