Highly Diastereoselective Methylation of Five-Ring N,O-Acetals

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Journal Title

Journal ISSN

Volume Title

A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Date

2004

Major/Subject

Mcode

Degree programme

Language

en

Pages

3
268-270

Series

LETTERS IN ORGANIC CHEMISTRY, Volume 1, issue 3

Abstract

Highly diastereoselective methylation of (2S,4S)- and (2R,4S)-3-tert-butyl 4-methyl 2-tertbutyloxazolidine-3,4-dicarboxylate (1a/b) is reported. The relative and absolute configuration of the methylated products was assigned by NOESY and confirmed by a crystal structure of 1a.

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Keywords

alkylation, amino acids, diastereoselectivity

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Citation

Koskinen , A M P , Brunner , M , Straub , T , Saarenketo , P & Rissanen , K 2004 , ' Highly Diastereoselective Methylation of Five-Ring N,O-Acetals ' , Letters in Organic Chemistry , vol. 1 , no. 3 , pp. 268-270 .