Nanoswimmers Based on Capped Janus Nanospheres
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
Materials, Volume 15, issue 13
AbstractNanoswimmers are synthetic nanoscale objects that convert the available surrounding free energy to a directed motion. For example, bacteria with various flagella types serve as textbook examples of the minuscule swimmers found in nature. Along these lines, a plethora of artificial hybrid and non-hybrid nanoswimmers have been introduced, and they could find many uses, e.g., for targeted drug delivery systems (TDDSs) and controlled drug treatments. Here, we discuss a certain class of nanoparticles, i.e., functional, capped Janus nanospheres that can be employed as nanoswimmers, their subclasses and properties, as well as their various implementations. A brief outlook is given on different fabrication and synthesis methods, as well as on the diverse compositions used to prepare nanoswimmers, with a focus on the particle types and materials suitable for biomedical applications. Several recent studies have shown remarkable success in achieving temporally and spatially controlled drug delivery in vitro using Janus-particle-based TDDSs. We believe that this review will serve as a concise introductory synopsis for the interested readers. Therefore, we hope that it will deepen the general understanding of nanoparticle behavior in biological matrices.
Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
biohybrids, biomedicine, Janus particles, nanofabrication, nanospheres, nanoswimmers, targeted delivery
Piskunen , P , Huusela , M & Linko , V 2022 , ' Nanoswimmers Based on Capped Janus Nanospheres ' , Materials , vol. 15 , no. 13 , 4442 . https://doi.org/10.3390/ma15134442