Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorThiede, A.en_US
dc.contributor.authorGlerean, E.en_US
dc.contributor.authorKujala, T.en_US
dc.contributor.authorParkkonen, L.en_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationUniversity of Helsinkien_US
dc.date.accessioned2020-06-25T08:42:58Z
dc.date.available2020-06-25T08:42:58Z
dc.date.issued2020-08-01en_US
dc.description.abstractListening to speech elicits brain activity time-locked to the speech sounds. This so-called neural entrainment to speech was found to be atypical in dyslexia, a reading impairment associated with neural speech processing deficits. We hypothesized that the brain responses of dyslexic vs. normal readers to real-life speech would be different, and thus the strength of inter-subject correlation (ISC) would differ from that of typical readers and be reflected in reading-related measures. We recorded magnetoencephalograms (MEG) of 23 dyslexic and 21 typically-reading adults during listening to ~10 ​min of natural Finnish speech consisting of excerpts from radio news, a podcast, a self-recorded audiobook chapter and small talk. The amplitude envelopes of band-pass-filtered MEG source signals were correlated between subjects in a cortically-constrained source space in six frequency bands. The resulting ISCs of dyslexic and typical readers were compared with a permutation-based t-test. Neuropsychological measures of phonological processing, technical reading, and working memory were correlated with the ISCs utilizing the Mantel test. During listening to speech, ISCs were mainly reduced in dyslexic compared to typical readers in delta (0.5–4 ​Hz) and high gamma (55–90 ​Hz) frequency bands. In the theta (4–8 ​Hz), beta (12–25 ​Hz), and low gamma (25–45 ​Hz) bands, dyslexics had enhanced ISCs to speech compared to controls. Furthermore, we found that ISCs across both groups were associated with phonological processing, technical reading, and working memory. The atypical ISCs to natural speech in dyslexics supports the temporal sampling deficit theory of dyslexia. It also suggests over-synchronization to phoneme-rate information in speech, which could indicate more effort-demanding sampling of phonemes from speech in dyslexia. These irregularities in parsing speech are likely some of the complex neural factors contributing to dyslexia. The associations between neural coupling and reading-related skills further support this notion.en
dc.description.versionPeer revieweden
dc.format.extent15
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationThiede, A, Glerean, E, Kujala, T & Parkkonen, L 2020, ' Atypical MEG inter-subject correlation during listening to continuous natural speech in dyslexia ', NeuroImage, vol. 216, 116799 . https://doi.org/10.1016/j.neuroimage.2020.116799en
dc.identifier.doi10.1016/j.neuroimage.2020.116799en_US
dc.identifier.issn1053-8119
dc.identifier.issn1095-9572
dc.identifier.otherPURE UUID: d41766d6-cba9-4a96-8010-8265fa61fb43en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/d41766d6-cba9-4a96-8010-8265fa61fb43en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85084209907&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/43322321/Thiede_Atypical.1_s2.0_S105381192030286X_main.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/45222
dc.identifier.urnURN:NBN:fi:aalto-202006254179
dc.language.isoenen
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofseriesNeuroImageen
dc.relation.ispartofseriesVolume 216en
dc.rightsopenAccessen
dc.subject.keywordDyslexiaen_US
dc.subject.keywordInter-subject correlationen_US
dc.subject.keywordMagnetoencephalographyen_US
dc.subject.keywordNatural speechen_US
dc.subject.keywordReading skillsen_US
dc.titleAtypical MEG inter-subject correlation during listening to continuous natural speech in dyslexiaen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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