Microscopic Mechanism for Cold Denaturation

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorDias, Cristiano L.
dc.contributor.authorAla-Nissilä, Tapio
dc.contributor.authorKarttunen, Mikko
dc.contributor.authorVattulainen, Ilpo
dc.contributor.authorGrant, Martin
dc.contributor.departmentTeknillisen fysiikan laitosfi
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.schoolPerustieteiden korkeakoulufi
dc.contributor.schoolSchool of Scienceen
dc.date.accessioned2015-04-29T09:01:12Z
dc.date.available2015-04-29T09:01:12Z
dc.date.issued2008
dc.description.abstractWe elucidate the mechanism of cold denaturation through constant-pressure simulations for a model of hydrophobic molecules in an explicit solvent. We find that the temperature dependence of the hydrophobic effect induces, facilitates, and is the driving force for cold denaturation. The physical mechanism underlying this phenomenon is identified as the destabilization of hydrophobic contact in favor of solvent-separated configurations, the same mechanism seen in pressure-induced denaturation. A phenomenological explanation proposed for the mechanism is suggested as being responsible for cold denaturation in real proteins.en
dc.description.versionPeer revieweden
dc.format.extent118101/1-4
dc.format.mimetypeapplication/pdfen
dc.identifier.citationDias, Cristiano L. & Ala-Nissilä, Tapio & Karttunen, Mikko & Vattulainen, Ilpo & Grant, Martin. 2008. Microscopic Mechanism for Cold Denaturation. Physical Review Letters. Volume 100, Issue 11. P. 118101/1-4. ISSN 0031-9007 (printed). DOI: 10.1103/physrevlett.100.118101.en
dc.identifier.doi10.1103/physrevlett.100.118101
dc.identifier.issn0031-9007 (printed)
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/15837
dc.identifier.urnURN:NBN:fi:aalto-201504292497
dc.language.isoenen
dc.publisherAmerican Physical Society (APS)en
dc.relation.ispartofseriesPhysical Review Lettersen
dc.relation.ispartofseriesVolume 100, Issue 11
dc.rights© 2008 American Physical Society (APS). http://www.aps.org/en
dc.rights.holderAmerican Physical Society (APS)
dc.subject.keywordproteinsen
dc.subject.keywordprotein unfoldingen
dc.subject.keyworddenaturationen
dc.subject.otherPhysicsen
dc.titleMicroscopic Mechanism for Cold Denaturationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.dcmitypetexten
dc.type.versionFinal published versionen

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