Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity

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Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-12-20
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Language
en
Pages
6
46843-46848
Series
ACS Omega, Volume 7, issue 50
Abstract
Analogues of benzene-1,3,5-tricarboxamide bearing combinations of different alkyl chains (dodecyl to octadecyl) and ester-linked PEG (polyethylene glycol) chains are shown to self-assemble into either micelles or nanotapes in aqueous solution, depending on the architecture (number of alkyl vs PEG chains). The cytotoxicity to cells is selectively greater for breast cancer cells than fibroblast controls in a dose-dependent manner. The compounds show strong stability, retaining their self-assembled structures at low pH (relevant to acidic tumor conditions) and in buffer and cell culture media.
Description
Funding Information: N.A. acknowledges support from the Saudi Arabian Cultural Bureau. I.W.H. thanks EPSRC for the award of an Established Career Fellowship (ref EP/V053396/1). We thank Diamond Light Source for the award of beamtime (ref sm28659-1 and -2) and Barbara Gerbelli (FAPESP-funded visiting postdoc at University of Reading), Nathan Cowieson (Diamond), and Katsuaki Inoue (Diamond) for assistance with the SAXS measurements. We are grateful to Az Alddien Natfji (University of Reading) for help with cell assays. Publisher Copyright: © 2022 American Chemical Society.
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Citation
Aljuaid , N , Seitsonen , J , Ruokolainen , J , Greco , F & Hamley , I W 2022 , ' Micelle and Nanotape Formation of Benzene Tricarboxamide Analogues with Selective Cancer Cell Cytotoxicity ' , ACS Omega , vol. 7 , no. 50 , pp. 46843-46848 . https://doi.org/10.1021/acsomega.2c05940