TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2023-03
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Language
en
Pages
11
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Brain Sciences, Volume 13, issue 3
Abstract
Coregistration of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) allows non-invasive probing of brain circuits: TMS induces brain activation due to the generation of a properly oriented focused electric field (E-field) using a coil placed on a selected position over the scalp, while EEG captures the effects of the stimulation on brain electrical activity. Moreover, the combination of these techniques allows the investigation of several brain properties, including brain functional connectivity. The choice of E-field parameters, such as intensity, orientation, and position, is crucial for eliciting cortex-specific effects. Here, we evaluated whether and how the spatial pattern, i.e., topography and strength of functional connectivity, is modulated by the stimulus orientation. We systematically altered the E-field orientation when stimulating the left pre-supplementary motor area and showed an increase of functional connectivity in areas associated with the primary motor cortex and an E-field orientation-specific modulation of functional connectivity intensity.Description
Funding Information: This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No. 810377). VHS is funded by the Academy of Finland (decision No. 349985). | openaire: EC/H2020/810377/EU//ConnectToBrain
Keywords
functional connectivity, stimulus orientation, TMS-EEG
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Citation
Pieramico, G, Guidotti, R, Nieminen, A E, D’Andrea, A, Basti, A, Souza, V H, Nieminen, J O, Lioumis, P, Ilmoniemi, R J, Romani, G L, Pizzella, V & Marzetti, L 2023, ' TMS-Induced Modulation of EEG Functional Connectivity Is Affected by the E-Field Orientation ', Brain Sciences, vol. 13, no. 3, 418 . https://doi.org/10.3390/brainsci13030418