Disentangling the Role of Working Memory in Parkinson’s Disease

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorSalmi, Juhaen_US
dc.contributor.authorRitakallio, Liisaen_US
dc.contributor.authorFellman, Danielen_US
dc.contributor.authorEllfolk, Ullaen_US
dc.contributor.authorRinne, Juha O.en_US
dc.contributor.authorLaine, Mattien_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationÅbo Akademi Universityen_US
dc.contributor.organizationTurku University Hospitalen_US
dc.date.accessioned2020-10-30T12:46:20Z
dc.date.available2020-10-30T12:46:20Z
dc.date.issued2020-09-25en_US
dc.description.abstractWorking memory (WM) represents a core cognitive function with a major striatal contribution, and thus WM deficits, commonly observed in Parkinson’s disease (PD), could also relate to many other problems in PD patients. Our online study aimed to determine the subdomains of WM that are particularly affected in PD and to clarify the links between WM and everyday cognitive deficits, other executive functions, psychiatric and PD symptoms, as well as early cognitive impairment. Fifty-two mild-to-moderate PD patients and 54 healthy controls performed seven WM tasks tapping selective updating, continuous monitoring, or maintenance of currently active information. Self-ratings of everyday cognition, depression, and apathy symptoms, as well as screenings of global cognitive impairment, were also collected. The data were analyzed using structural equation modeling. Of the three WM domains, only selective updating was directly predictive of PD group membership. More widespread WM deficits were observed only in relation to global cognitive impairment in PD patients. Self-rated everyday cognition or psychiatric symptoms were not linked to WM performance but correlated with each other. Our findings suggest that WM has a rather limited role in the clinical manifestation of PD. Nevertheless, due to its elementary link to striatal function, the updating component of WM could be a candidate for a cognitive marker of PD also in patients who are otherwise cognitively well-preserved.en
dc.description.versionPeer revieweden
dc.format.extent17
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationSalmi, J, Ritakallio, L, Fellman, D, Ellfolk, U, Rinne, J O & Laine, M 2020, ' Disentangling the Role of Working Memory in Parkinson’s Disease ', Frontiers in Aging Neuroscience, vol. 12, 572037 . https://doi.org/10.3389/fnagi.2020.572037en
dc.identifier.doi10.3389/fnagi.2020.572037en_US
dc.identifier.issn1663-4365
dc.identifier.otherPURE UUID: a1e8e918-f115-4b54-b268-82d2770e24fden_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/a1e8e918-f115-4b54-b268-82d2770e24fden_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85092277818&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/52474402/Salmi_Disentangling.fnagi_12_572037.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/47338
dc.identifier.urnURN:NBN:fi:aalto-202010306221
dc.language.isoenen
dc.publisherFrontiers Research Foundation
dc.relation.ispartofseriesFrontiers in Aging Neuroscienceen
dc.relation.ispartofseriesVolume 12en
dc.rightsopenAccessen
dc.subject.keywordaffective symptomsen_US
dc.subject.keywordcognitive impairmenten_US
dc.subject.keyworddepressionen_US
dc.subject.keywordParkinson’s diseaseen_US
dc.subject.keywordworking memoryen_US
dc.titleDisentangling the Role of Working Memory in Parkinson’s Diseaseen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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