Development of hybrid hydrogels from cellulose nanofibrils and aloe vera extract

Abstract

This thesis presents the development and characterization of hybrid hydrogels synthesized from cellulose nanofibrils (CNF) and Aloe vera extract. The research objective was to harness the unique properties of CNF, such as biocompatibility and high mechanical strength, in conjunction with the therapeutic and bioactive features of Aloe vera, to create a new class of hybrid hydrogels. These hydrogels aim to offer potential applications in biomedical fields, particularly in wound healing and drug delivery systems.

The methodology employed a systematic approach, involving the extraction of cellulose nanofibrils using a combination of mechanical and chemical processes. The Aloe vera extract was incorporated into the CNF matrix through a cross-linking process, optimized to retain the biological efficacy of Aloe vera while ensuring structural integrity. The resultant hydrogels were characterized for their physical and chemical properties using various analytical techniques such as Scanning Electron Microscopy (SEM) and Fourier-Transform Infrared Spectroscopy (FTIR).

The results demonstrated that the hybrid hydrogels possess enhanced mechanical properties, improved water retention, and commendable biocompatibility, making them suitable for biomedical applications. The presence of Aloe vera contributed to the hydrogels’ bioactivity.

The thesis concludes with a discussion of the implications of these findings for future research and potential applications in biomedicine and materials science. It also outlines the limitations of the current study and proposes directions for future work to further enhance the properties and applications of these hybrid hydrogels.