Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter
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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Date
2014
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en
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Molecules, Volume 19, issue 2, pp. 1544-1567
Abstract
1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important group of compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have been the target of extensive synthetic efforts due to the presence of the scaffold in numerous natural products and synthetic targets. This review briefly summarizes the methods to obtain the C1 stereocenter and concentrates on evaluating the pharmacological importance of optically active C1-substituted THβCs, including their PDE5-inhibitory, antimalarial, antiviral and antitumor activities.Description
Keywords
tetrahydro-beta-carboline, TH-beta-C, pharmacological importance, biological activity, C1-substituted TH-beta-C
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Citation
Laine, A E, Lood, C & Koskinen, A M P 2014, ' Pharmacological Importance of Optically Active Tetrahydro-beta-carbolines and Synthetic Approaches to Create the C1 Stereocenter ', Molecules, vol. 19, no. 2, pp. 1544-1567 . https://doi.org/10.3390/molecules19021544