Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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11
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Nanomedicine: Nanotechnology, Biology and Medicine, Volume 13, issue 2, pp. 515-525
Abstract
The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.Description
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Marques, J, Valle-Delgado, J J, Urbán, P, Baró, E, Prohens, R, Mayor, A, Cisteró, P, Delves, M, Sinden, R E, Grandfils, C, de Paz, J L, García-Salcedo, J A & Fernàndez-Busquets, X 2017, 'Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery', Nanomedicine: Nanotechnology, Biology and Medicine, vol. 13, no. 2, pp. 515-525. https://doi.org/10.1016/j.nano.2016.09.010