Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-08
Major/Subject
Mcode
Degree programme
Language
en
Pages
10
2200807
Series
Small, Volume 18, issue 32
Abstract
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.
Description
Tallenna OA-artikkeli, kun julkaistu
Keywords
bromination, elastomers, halogen bonding, peptides, resilin, self-assembly, supramolecular chemistry
Other note
Citation
Pizzi, A, Sori, L, Pigliacelli, C, Gautieri, A, Andolina, C, Bergamaschi, G, Gori, A, Panine, P, Grande, A M, Linder, M B, Baldelli Bombelli, F, Soncini, M & Metrangolo, P 2022, ' Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination ', Small, vol. 18, no. 32, 2200807, pp. 2200807 . https://doi.org/10.1002/smll.202200807