Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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10
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Small, Volume 18, issue 32, pp. 2200807
Abstract
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.Description
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Pizzi, A, Sori, L, Pigliacelli, C, Gautieri, A, Andolina, C, Bergamaschi, G, Gori, A, Panine, P, Grande, A M, Linder, M B, Baldelli Bombelli, F, Soncini, M & Metrangolo, P 2022, 'Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination', Small, vol. 18, no. 32, 2200807, pp. 2200807. https://doi.org/10.1002/smll.202200807