Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorRoychoudhury, Shubhadeepen_US
dc.contributor.authorDas, Dipikaen_US
dc.contributor.authorDas, Sandipanen_US
dc.contributor.authorJha, Niraj Kumaren_US
dc.contributor.authorPal, Mahadeben_US
dc.contributor.authorKolesarova, Adrianaen_US
dc.contributor.authorKesari, Kavindra Kumaren_US
dc.contributor.authorKalita, Jogen C.en_US
dc.contributor.authorSlama, Petren_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.groupauthorWood Chemistryen
dc.contributor.organizationAssam Universityen_US
dc.contributor.organizationSharda Universityen_US
dc.contributor.organizationBose Instituteen_US
dc.contributor.organizationSlovak University of Agriculture in Nitraen_US
dc.contributor.organizationGauhati Universityen_US
dc.contributor.organizationMendel University in Brnoen_US
dc.date.accessioned2022-11-23T07:58:51Z
dc.date.available2022-11-23T07:58:51Z
dc.date.issued2022-10en_US
dc.descriptionPublisher Copyright: © 2022 by the authors.
dc.description.abstractHerbal products have been used in traditional systems of medicine and by ethnic healers for ages to treat various diseases. Currently, it is estimated that about 80% of people worldwide use herbal traditional medicines against various ailments, partly due to easy accessibility and low cost, and the lower side effects they pose. Bergenia ligulata, a herb ranging from the Himalayas to the foothills, including the north-eastern states of India, has traditionally been used as a remedy against various diseases, most prominently kidney stones. The medicinal properties of B. ligulata have been attributed to bergenin, its most potent bioactive component. Apart from bergenin, the other compounds available in B. ligulata are arbutin, gallic acid, protocatechuic acid, chlorogenic acid, syringic acid, catechin, ferulic acid, afzelechin, paashaanolactone, caryophyllene, 1,8-cineole, β-eudesmol, stigmasterol, β-sitosterol, parasorbic acid, 3-methyl-2-buten-1-ol, phytol, terpinen-4-ol, tannic acid, isovalaric acid, avicularin, quercetin, reynoutrin, and sitoinoside I. This review summarizes various medicinal properties of the herb, along with providing deep insight into its bioactive molecules and their potential roles in the amelioration of human ailments. Additionally, the possible mechanism(s) of action of the herb’s anti-urolithiatic, antioxidative, antipyretic, anti-diabetic, anti-inflammatory and hepatoprotective properties are discussed. This comprehensive documentation will help researchers to better understand the medicinal uses of the herb. Further studies on B. ligulata can lead to the discovery of new drug(s) and therapeutics for various ailments.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationRoychoudhury, S, Das, D, Das, S, Jha, N K, Pal, M, Kolesarova, A, Kesari, K K, Kalita, J C & Slama, P 2022, ' Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study ', Molecules, vol. 27, no. 20, 7039 . https://doi.org/10.3390/molecules27207039en
dc.identifier.doi10.3390/molecules27207039en_US
dc.identifier.issn1420-3049
dc.identifier.otherPURE UUID: 025bfba3-b1b4-4c3a-8d8a-7018aca1a864en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/025bfba3-b1b4-4c3a-8d8a-7018aca1a864en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85140794173&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/91831116/CHEM_Roychoudhury_et_al_Clinical_Potential_of_Himalayan_2022_Molecules.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/117785
dc.identifier.urnURN:NBN:fi:aalto-202211236545
dc.language.isoenen
dc.publisherMDPI AG
dc.relation.ispartofseriesMoleculesen
dc.relation.ispartofseriesVolume 27, issue 20en
dc.rightsopenAccessen
dc.subject.keywordanti-diabeticen_US
dc.subject.keywordanti-inflammatoryen_US
dc.subject.keywordanti-pyreticen_US
dc.subject.keywordanti-urolithiaticen_US
dc.subject.keywordantioxidanten_US
dc.subject.keywordBergenia ligulataen_US
dc.subject.keywordbioactive compoundsen_US
dc.subject.keywordcardiovascular diseasesen_US
dc.subject.keywordtraditional medicineen_US
dc.titleClinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Studyen
dc.typeA2 Katsausartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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