Driving operational excellence: Application of lean practices to minimize turnaround time in a pharmaceutical manufacturing company

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.advisorGhadimi, Pezhman
dc.contributor.authorSuleman, Muhammad Iqbal
dc.contributor.schoolInsinööritieteiden korkeakoulufi
dc.contributor.supervisorSalmi, Mika
dc.date.accessioned2023-09-10T17:01:43Z
dc.date.available2023-09-10T17:01:43Z
dc.date.issued2023-08-30
dc.description.abstractThe purpose of this thesis is to apply Lean practices in a pharmaceutical manufacturing company and demonstrate the effectiveness of Lean in the pharmaceutical industry. The objective is to reduce turnaround time (TAT) in a filling by 30%, the defect rate of manifold tubing by 50%, and develop standardized work using an integrated approach of different Lean tools. Frameworks for problem-solving Plan, Do, Check, Act (PDCA) the defect rate, standard work for streamlining the processes, and Single Minute Exchange of Dies (SMED) for investigating downtime were setup with instructions and guidelines considering the limitations of a pharmaceutical manufacturing company. The defect rate was reduced by 66.5%, TAT by 29%, standardized work was developed using the following Lean tools: process mapping, standard work combination table, operator balance chart, Kanban, and 5S. This thesis demonstrates the effectiveness of applying Lean in a pharmaceutical company. It contributes to literature in a novel way by utilizing PDCA to identify the root cause of defects in manifold tubing in a detailed manner that has not been documented previously.en
dc.format.extent50+2
dc.format.mimetypeapplication/pdfen
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/123414
dc.identifier.urnURN:NBN:fi:aalto-202309105774
dc.language.isoenen
dc.programmeMaster’s programme in Manufacturingfi
dc.programme.majorZero Defect Manufacture for a Circular Economyfi
dc.programme.mcodefi
dc.subject.keywordleanen
dc.subject.keywordpharmaceutical manufacturingen
dc.subject.keywordprocess improvementen
dc.subject.keywordPDCAen
dc.titleDriving operational excellence: Application of lean practices to minimize turnaround time in a pharmaceutical manufacturing companyen
dc.typeG2 Pro gradu, diplomityöfi
dc.type.ontasotMaster's thesisen
dc.type.ontasotDiplomityöfi
local.aalto.electroniconlyyes
local.aalto.openaccessyes
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